David Sinclair headshot

David Andrew Sinclair, Ph.D.

Professor of Genetics
Sinclair Lab Website
Measuring PGC-1a and its acetylation status in mouse primary myotubes.
Authors: Authors: Gomes AP, Sinclair DA.
Methods Mol Biol
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Correction: nicotinamide impairs entry into and exit from meiosis I in mouse oocytes.
Authors: Authors: Riepsamen A, Wu L, Lau L, Listijono D, Ledger W, Sinclair DA, Homer H.
PLoS One
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The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.
Authors: Authors: Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Lüscher TF, Matter CM.
Eur Heart J
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Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes.
Authors: Authors: Riepsamen A, Wu L, Lau L, Listijono D, Ledger W, Sinclair D, Homer H.
PLoS One
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Dietary restriction involves NAD? -dependent mechanisms and a shift toward oxidative metabolism.
Authors: Authors: Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK.
Aging Cell
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SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Authors: Authors: Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R.
Aging Cell
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An apparatus to manipulate and identify individual Ba ions from bulk liquid Xe.
Authors: Authors: Twelker K, Kravitz S, Montero Díez M, Gratta G, Fairbank W, Albert JB, Auty DJ, Barbeau PS, Beck D, Benitez-Medina C, Breidenbach M, Brunner T, Cao GF, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, Daugherty SJ, Davis CG, DeVoe R, Delaquis S, Didberidze T, Dilling J, Dolinski MJ, Dunford M, Fabris L, Farine J, Feldmeier W, Fierlinger P, Fudenberg D, Giroux G, Gornea R, Graham K, Hall C, Heffner M, Herrin S, Hughes M, Jiang XS, Johnson TN, Johnston S, Karelin A, Kaufman LJ, Killick R, Koffas T, Krücken R, Kuchenkov A, Kumar KS, Leonard DS, Leonard F, Licciardi C, Lin YH, MacLellan R, Marino MG, Mong B, Moore D, Odian A, Ostrovskiy I, Ouellet C, Piepke A, Pocar A, Retiere F, Rowson PC, Rozo MP, Schubert A, Sinclair D, Smith E, Stekhanov V, Tarka M, Tolba T, Tosi D, Vuilleumier JL, Walton J, Walton T, Weber M, Wen LJ, Wichoski U, Yang L, Yen YR, Zhao YB.
Rev Sci Instrum
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The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease.
Authors: Authors: Cronise RJ, Sinclair DA, Bremer AA.
Metab Syndr Relat Disord
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Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells.
Authors: Authors: Rimmelé P, Bigarella CL, Liang R, Izac B, Dieguez-Gonzalez R, Barbet G, Donovan M, Brugnara C, Blander JM, Sinclair DA, Ghaffari S.
Stem Cell Reports
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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.
Authors: Authors: North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA.
EMBO J
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