Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies.
Authors: Authors: Verkoczy L, Alt FW, Tian M.
Immunol Rev
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Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration.
Authors: Authors: Birtolo C, Pham H, Morvaridi S, Chheda C, Go VL, Ptasznik A, Edderkaoui M, Weisman MH, Noss E, Brenner MB, Larson B, Guindi M, Wang Q, Pandol SJ.
Am J Pathol
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Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.
Authors: Authors: Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RVV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Williams A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM.
Wellcome Open Res
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An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vd and Dd Gene Segments.
Authors: Authors: Chen L, Zhao L, Alt FW, Krangel MS.
J Immunol
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PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line.
Authors: Authors: Kumar V, Alt FW, Frock RL.
Proc Natl Acad Sci U S A
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Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.
Authors: Authors: Tian M, Cheng C, Chen X, Duan H, Cheng HL, Dao M, Sheng Z, Kimble M, Wang L, Lin S, Schmidt SD, Du Z, Joyce MG, Chen Y, DeKosky BJ, Chen Y, Normandin E, Cantor E, Chen RE, Doria-Rose NA, Zhang Y, Shi W, Kong WP, Choe M, Henry AR, Laboune F, Georgiev IS, Huang PY, Jain S, McGuire AT, Georgeson E, Menis S, Douek DC, Schief WR, Stamatatos L, Kwong PD, Shapiro L, Haynes BF, Mascola JR, Alt FW.
Cell
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Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.
Authors: Authors: Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW.
J Exp Med
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Activation strategies for invariant natural killer T cells.
Authors: Authors: Kohlgruber AC, Donado CA, LaMarche NM, Brenner MB, Brennan PJ.
Immunogenetics
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Highly sensitive and unbiased approach for elucidating antibody repertoires.
Authors: Authors: Lin SG, Ba Z, Du Z, Zhang Y, Hu J, Alt FW.
Proc Natl Acad Sci U S A
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A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair.
Authors: Authors: Encarnação M, Espada L, Escrevente C, Mateus D, Ramalho J, Michelet X, Santarino I, Hsu VW, Brenner MB, Barral DC, Vieira OV.
J Cell Biol
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