Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.

Authors: Authors: Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW.
J Exp Med 2016-08-22
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Activation strategies for invariant natural killer T cells.

Authors: Authors: Kohlgruber AC, Donado CA, LaMarche NM, Brenner MB, Brennan PJ.
Immunogenetics 2016-08-01
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Highly sensitive and unbiased approach for elucidating antibody repertoires.

Authors: Authors: Lin SG, Ba Z, Du Z, Zhang Y, Hu J, Alt FW.
Proc Natl Acad Sci U S A 2016-07-12
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A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair.

Authors: Authors: Encarnação M, Espada L, Escrevente C, Mateus D, Ramalho J, Michelet X, Santarino I, Hsu VW, Brenner MB, Barral DC, Vieira OV.
J Cell Biol 2016-06-20
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Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181.

Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
J Immunol 2016-05-01
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Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181.

Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
J Immunol 2016-05-01
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Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing.

Authors: Authors: Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL.
Nat Protoc 2016-05-01
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Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149.

Authors: Authors: Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS.
J Immunol 2016-05-01
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Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells.

Authors: Authors: Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW.
Proc Natl Acad Sci U S A 2016-02-23
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Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells.

Authors: Authors: Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B.
Cell 2016-02-11
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