Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181.

Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
J Immunol 2016-05-01
View full abstract on Pubmed

Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181.

Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
J Immunol 2016-05-01
View full abstract on Pubmed

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing.

Authors: Authors: Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL.
Nat Protoc 2016-05-01
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Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149.

Authors: Authors: Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS.
J Immunol 2016-05-01
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Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells.

Authors: Authors: Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW.
Proc Natl Acad Sci U S A 2016-02-23
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Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells.

Authors: Authors: Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B.
Cell 2016-02-11
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Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region.

Authors: Authors: Garot A, Marquet M, Saintamand A, Bender S, Le Noir S, Rouaud P, Carrion C, Oruc Z, Bébin AG, Moreau J, Lebrigand K, Denizot Y, Alt FW, Cogné M, Pinaud E.
Proc Natl Acad Sci U S A 2016-02-09
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Human autoreactive T cells recognize CD1b and phospholipids.

Authors: Authors: Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB.
Proc Natl Acad Sci U S A 2016-01-12
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Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types.

Authors: Authors: Noss EH, Nguyen HN, Chang SK, Watts GF, Brenner MB.
Proc Natl Acad Sci U S A 2015-12-01
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Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes.

Authors: Authors: Yeap LS, Hwang JK, Du Z, Meyers RM, Meng FL, Jakubauskaite A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH, Alt FW.
Cell 2015-11-19
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