Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes.
Authors: Authors: Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW.
Cell
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Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells.
Authors: Authors: Wolf BJ, Tatituri RV, Almeida CF, Le Nours J, Bhowruth V, Johnson D, Uldrich AP, Hsu FF, Brigl M, Besra GS, Rossjohn J, Godfrey DI, Brenner MB.
J Immunol
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Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.
Authors: Authors: Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW.
Nature
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Immune cell profiling to guide therapeutic decisions in rheumatic diseases.
Authors: Authors: Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S.
Nat Rev Rheumatol
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A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.
Authors: Authors: Ba Z, Meng FL, Gostissa M, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, Alt FW.
Cancer Immunol Res
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Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.
Authors: Authors: Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB.
Arthritis Res Ther
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An oncogenic role for alternative NF-?B signaling in DLBCL revealed upon deregulated BCL6 expression.
Authors: Authors: Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, Rajewsky K.
Cell Rep
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Aberrant TCRd rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.
Authors: Authors: Jiang W, Lee BJ, Li C, Dubois RL, Gostissa M, Alt FW, Zha S.
Blood
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MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b.
Authors: Authors: Michelet X, Garg S, Wolf BJ, Tuli A, Ricciardi-Castagnoli P, Brenner MB.
J Immunol
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Characterization of polar lipids of Listeria monocytogenes by HCD and low-energy CAD linear ion-trap mass spectrometry with electrospray ionization.
Authors: Authors: Tatituri RV, Wolf BJ, Brenner MB, Turk J, Hsu FF.
Anal Bioanal Chem
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