Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region.

Authors: Authors: Garot A, Marquet M, Saintamand A, Bender S, Le Noir S, Rouaud P, Carrion C, Oruc Z, Bébin AG, Moreau J, Lebrigand K, Denizot Y, Alt FW, Cogné M, Pinaud E.
Proc Natl Acad Sci U S A 2016-02-09
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Human autoreactive T cells recognize CD1b and phospholipids.

Authors: Authors: Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB.
Proc Natl Acad Sci U S A 2016-01-12
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Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types.

Authors: Authors: Noss EH, Nguyen HN, Chang SK, Watts GF, Brenner MB.
Proc Natl Acad Sci U S A 2015-12-01
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Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes.

Authors: Authors: Yeap LS, Hwang JK, Du Z, Meyers RM, Meng FL, Jakubauskaite A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH, Alt FW.
Cell 2015-11-19
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Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes.

Authors: Authors: Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW.
Cell 2015-11-05
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Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells.

Authors: Authors: Wolf BJ, Tatituri RV, Almeida CF, Le Nours J, Bhowruth V, Johnson D, Uldrich AP, Hsu FF, Brigl M, Besra GS, Rossjohn J, Godfrey DI, Brenner MB.
J Immunol 2015-09-15
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Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

Authors: Authors: Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW.
Nature 2015-09-03
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Immune cell profiling to guide therapeutic decisions in rheumatic diseases.

Authors: Authors: Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S.
Nat Rev Rheumatol 2015-09-01
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A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.

Authors: Authors: Ba Z, Meng FL, Gostissa M, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, Alt FW.
Cancer Immunol Res 2015-06-01
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Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.

Authors: Authors: Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB.
Arthritis Res Ther 2015-05-15
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