Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Immune cell profiling to guide therapeutic decisions in rheumatic diseases.
Authors: Authors: Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S.
Nat Rev Rheumatol
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A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.
Authors: Authors: Ba Z, Meng FL, Gostissa M, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, Alt FW.
Cancer Immunol Res
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Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.
Authors: Authors: Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB.
Arthritis Res Ther
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An oncogenic role for alternative NF-?B signaling in DLBCL revealed upon deregulated BCL6 expression.
Authors: Authors: Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, Rajewsky K.
Cell Rep
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Aberrant TCRd rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.
Authors: Authors: Jiang W, Lee BJ, Li C, Dubois RL, Gostissa M, Alt FW, Zha S.
Blood
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Characterization of polar lipids of Listeria monocytogenes by HCD and low-energy CAD linear ion-trap mass spectrometry with electrospray ionization.
Authors: Authors: Tatituri RV, Wolf BJ, Brenner MB, Turk J, Hsu FF.
Anal Bioanal Chem
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MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b.
Authors: Authors: Michelet X, Garg S, Wolf BJ, Tuli A, Ricciardi-Castagnoli P, Brenner MB.
J Immunol
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CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.
Authors: Authors: Lin SG, Guo C, Su A, Zhang Y, Alt FW.
Proc Natl Acad Sci U S A
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Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.
Authors: Authors: Hwang JK, Alt FW, Yeap LS.
Microbiol Spectr
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Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.
Authors: Authors: Frock RL, Hu J, Meyers RM, Ho YJ, Kii E, Alt FW.
Nat Biotechnol
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