Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.
Authors: Authors: Lin SG, Guo C, Su A, Zhang Y, Alt FW.
Proc Natl Acad Sci U S A
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Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.
Authors: Authors: Hwang JK, Alt FW, Yeap LS.
Microbiol Spectr
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Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.
Authors: Authors: Frock RL, Hu J, Meyers RM, Ho YJ, Kii E, Alt FW.
Nat Biotechnol
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The transcriptional programs of iNKT cells.
Authors: Authors: Kim EY, Lynch L, Brennan PJ, Cohen NR, Brenner MB.
Semin Immunol
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RNAi screens of lysosomal trafficking.
Authors: Authors: Garg S, Brenner MB.
Methods Cell Biol
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Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
Authors: Authors: Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB.
Nat Immunol
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Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.
Authors: Authors: Meng FL, Du Z, Federation A, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig MC, Bradner JE, Liu XS, Alt FW.
Cell
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Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.
Authors: Authors: Brennan PJ, Tatituri RV, Heiss C, Watts GF, Hsu FF, Veerapen N, Cox LR, Azadi P, Besra GS, Brenner MB.
Proc Natl Acad Sci U S A
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Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice.
Authors: Authors: Tepsuporn S, Hu J, Gostissa M, Alt FW.
Cancer Immunol Res
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Pillars article: analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- a/ß T cells demonstrates preferential use of several Vß genes and an invariant TCR a chain. J. Exp. Med. 1993. 178: 1-16.
Authors: Authors: Porcelli S, Yockey CE, Brenner MB, Balk SP.
J Immunol
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