Frederick Alt, Ph.D.
Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.
Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.
Authors: Authors: Hu J, Tepsuporn S, Meyers RM, Gostissa M, Alt FW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.
Authors: Authors: Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S.
PLoS Genet
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PLoS Genet
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Reprint of "Functional overlaps between XLF and the ATM-dependent DNA double strand break response".
Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.
Authors: Authors: Macdonald LE, Karow M, Stevens S, Auerbach W, Poueymirou WT, Yasenchak J, Frendewey D, Valenzuela DM, Giallourakis CC, Alt FW, Yancopoulos GD, Murphy AJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Functional overlaps between XLF and the ATM-dependent DNA double strand break response.
A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency.
Authors: Authors: Lee YN, Frugoni F, Dobbs K, Walter JE, Giliani S, Gennery AR, Al-Herz W, Haddad E, LeDeist F, Bleesing JH, Henderson LA, Pai SY, Nelson RP, El-Ghoneimy DH, El-Feky RA, Reda SM, Hossny E, Soler-Palacin P, Fuleihan RL, Patel NC, Massaad MJ, Geha RS, Puck JM, Palma P, Cancrini C, Chen K, Vihinen M, Alt FW, Notarangelo LD.
J Allergy Clin Immunol
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J Allergy Clin Immunol
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IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.
Authors: Authors: Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Soft matrix is a natural stimulator for cellular invasiveness.
Authors: Authors: Gu Z, Liu F, Tonkova EA, Lee SY, Tschumperlin DJ, Brenner MB.
Mol Biol Cell
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Mol Biol Cell
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iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo .
Authors: Authors: Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE.
Cancer Immunol Res
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Cancer Immunol Res
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Michael Neuberger (1953-2013).