Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.
Authors: Authors: Meng FL, Du Z, Federation A, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig MC, Bradner JE, Liu XS, Alt FW.
Cell
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Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.
Authors: Authors: Brennan PJ, Tatituri RV, Heiss C, Watts GF, Hsu FF, Veerapen N, Cox LR, Azadi P, Besra GS, Brenner MB.
Proc Natl Acad Sci U S A
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Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice.
Authors: Authors: Tepsuporn S, Hu J, Gostissa M, Alt FW.
Cancer Immunol Res
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Pillars article: analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- a/ß T cells demonstrates preferential use of several Vß genes and an invariant TCR a chain. J. Exp. Med. 1993. 178: 1-16.
Authors: Authors: Porcelli S, Yockey CE, Brenner MB, Balk SP.
J Immunol
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Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.
Authors: Authors: Hu J, Tepsuporn S, Meyers RM, Gostissa M, Alt FW.
Proc Natl Acad Sci U S A
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Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.
Authors: Authors: Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S.
PLoS Genet
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Reprint of "Functional overlaps between XLF and the ATM-dependent DNA double strand break response".
Authors: Authors: Kumar V, Alt FW, Oksenych V.
DNA Repair (Amst)
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Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.
Authors: Authors: Macdonald LE, Karow M, Stevens S, Auerbach W, Poueymirou WT, Yasenchak J, Frendewey D, Valenzuela DM, Giallourakis CC, Alt FW, Yancopoulos GD, Murphy AJ.
Proc Natl Acad Sci U S A
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A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency.
Authors: Authors: Lee YN, Frugoni F, Dobbs K, Walter JE, Giliani S, Gennery AR, Al-Herz W, Haddad E, LeDeist F, Bleesing JH, Henderson LA, Pai SY, Nelson RP, El-Ghoneimy DH, El-Feky RA, Reda SM, Hossny E, Soler-Palacin P, Fuleihan RL, Patel NC, Massaad MJ, Geha RS, Puck JM, Palma P, Cancrini C, Chen K, Vihinen M, Alt FW, Notarangelo LD.
J Allergy Clin Immunol
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Functional overlaps between XLF and the ATM-dependent DNA double strand break response.
Authors: Authors: Kumar V, Alt FW, Oksenych V.
DNA Repair (Amst)
View full abstract on Pubmed