Frederick Alt, Ph.D.
Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.
IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.
Authors: Authors: Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Soft matrix is a natural stimulator for cellular invasiveness.
Authors: Authors: Gu Z, Liu F, Tonkova EA, Lee SY, Tschumperlin DJ, Brenner MB.
Mol Biol Cell
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Mol Biol Cell
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iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo .
Authors: Authors: Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE.
Cancer Immunol Res
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Cancer Immunol Res
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Michael Neuberger (1953-2013).
Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.
Authors: Authors: Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB.
Mol Biol Cell
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Mol Biol Cell
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Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus.
Authors: Authors: Dougan SK, Ashour J, Karssemeijer RA, Popp MW, Avalos AM, Barisa M, Altenburg AF, Ingram JR, Cragnolini JJ, Guo C, Alt FW, Jaenisch R, Ploegh HL.
Nature
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Nature
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Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells.
Authors: Authors: Hu X, Kim H, Brennan PJ, Han B, Baecher-Allan CM, De Jager PL, Brenner MB, Raychaudhuri S.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.
Authors: Authors: Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D.
Cell Rep
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Cell Rep
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Microbial colonization influences early B-lineage development in the gut lamina propria.
Authors: Authors: Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW.
Nature
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Nature
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Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.
Authors: Authors: Medvedovic J, Ebert A, Tagoh H, Tamir IM, Schwickert TA, Novatchkova M, Sun Q, Huis In 't Veld PJ, Guo C, Yoon HS, Denizot Y, Holwerda SJ, de Laat W, Cogné M, Shi Y, Alt FW, Busslinger M.
Immunity
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Immunity
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