Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.

Authors: Authors: Gostissa M, Bianco JM, Malkin DJ, Kutok JL, Rodig SJ, Morse HC, Bassing CH, Alt FW.
Proc Natl Acad Sci U S A 2013-02-19
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Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.

Authors: Authors: Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW.
Proc Natl Acad Sci U S A 2013-02-05
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Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.

Authors: Authors: Brennan PJ, Brigl M, Brenner MB.
Nat Rev Immunol 2013-02-01
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Mechanisms of programmed DNA lesions and genomic instability in the immune system.

Authors: Authors: Alt FW, Zhang Y, Meng FL, Guo C, Schwer B.
Cell 2013-01-31
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Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs.

Authors: Authors: Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M.
Proc Natl Acad Sci U S A 2013-01-29
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Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.

Authors: Authors: Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB.
Nat Immunol 2013-01-01
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Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.

Authors: Authors: Selimyan R, Gerstein RM, Ivanova I, Precht P, Subrahmanyam R, Perlot T, Alt FW, Sen R.
PLoS Biol 2013-01-01
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Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.

Authors: Authors: Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, Spring KJ, Alt FW, Khanna KK.
PLoS Genet 2013-01-01
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Arl13b regulates endocytic recycling traffic.

Authors: Authors: Barral DC, Garg S, Casalou C, Watts GF, Sandoval JL, Ramalho JS, Hsu VW, Brenner MB.
Proc Natl Acad Sci U S A 2012-12-26
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Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.

Authors: Authors: Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB.
Infect Immun 2012-12-01
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