Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.

Authors: Authors: Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D.
Cell Rep 2013-11-14
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Microbial colonization influences early B-lineage development in the gut lamina propria.

Authors: Authors: Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW.
Nature 2013-09-05
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Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.

Authors: Authors: Medvedovic J, Ebert A, Tagoh H, Tamir IM, Schwickert TA, Novatchkova M, Sun Q, Huis In 't Veld PJ, Guo C, Yoon HS, Denizot Y, Holwerda SJ, de Laat W, Cogné M, Shi Y, Alt FW, Busslinger M.
Immunity 2013-08-22
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53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

Authors: Authors: Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.
Cell 2013-06-06
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Genome architecture and expression.

Authors: Authors: Alt F, Almouzni G.
Curr Opin Genet Dev 2013-04-01
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Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.

Authors: Authors: Rass E, Chandramouly G, Zha S, Alt FW, Xie A.
J Biol Chem 2013-03-08
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CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells.

Authors: Authors: Sanderson JP, Brennan PJ, Mansour S, Matulis G, Patel O, Lissin N, Godfrey DI, Kawahara K, Zähringer U, Rossjohn J, Brenner MB, Gadola SD.
Eur J Immunol 2013-03-01
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Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.

Authors: Authors: Gostissa M, Bianco JM, Malkin DJ, Kutok JL, Rodig SJ, Morse HC, Bassing CH, Alt FW.
Proc Natl Acad Sci U S A 2013-02-19
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Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.

Authors: Authors: Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW.
Proc Natl Acad Sci U S A 2013-02-05
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Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.

Authors: Authors: Brennan PJ, Brigl M, Brenner MB.
Nat Rev Immunol 2013-02-01
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