Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.

Authors: Authors: Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB.
Nat Immunol 2013-01-01
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Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.

Authors: Authors: Selimyan R, Gerstein RM, Ivanova I, Precht P, Subrahmanyam R, Perlot T, Alt FW, Sen R.
PLoS Biol 2013-01-01
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Arl13b regulates endocytic recycling traffic.

Authors: Authors: Barral DC, Garg S, Casalou C, Watts GF, Sandoval JL, Ramalho JS, Hsu VW, Brenner MB.
Proc Natl Acad Sci U S A 2012-12-26
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Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions.

Authors: Authors: Subrahmanyam R, Du H, Ivanova I, Chakraborty T, Ji Y, Zhang Y, Alt FW, Schatz DG, Sen R.
Nat Immunol 2012-12-01
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Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.

Authors: Authors: Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB.
Infect Immun 2012-12-01
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Aquaporin 2 promotes cell migration and epithelial morphogenesis.

Authors: Authors: Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner MB, Van Hoek A, Xiong J, Gundersen GG, Norman JC, Hsu VW, Fenton RA, Brown D, Lu HA.
J Am Soc Nephrol 2012-09-01
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Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells.

Authors: Authors: Wesemann DR, Portuguese AJ, Magee JM, Gallagher MP, Zhou X, Panchakshari RA, Alt FW.
Proc Natl Acad Sci U S A 2012-08-21
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Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function.

Authors: Authors: Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, Eston MA, Alt FW, Terhorst C, Notarangelo LD, Snapper SB.
Blood 2012-04-26
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Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks.

Authors: Authors: Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ.
Nat Immunol 2012-04-01
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Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.

Authors: Authors: León L, Tatituri RV, Grenha R, Sun Y, Barral DC, Minnaard AJ, Bhowruth V, Veerapen N, Besra GS, Kasmar A, Peng W, Moody DB, Grabowski GA, Brenner MB.
Proc Natl Acad Sci U S A 2012-03-20
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