Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function.

Authors: Authors: Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, Eston MA, Alt FW, Terhorst C, Notarangelo LD, Snapper SB.
Blood 2012-04-26
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Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks.

Authors: Authors: Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ.
Nat Immunol 2012-04-01
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Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.

Authors: Authors: León L, Tatituri RV, Grenha R, Sun Y, Barral DC, Minnaard AJ, Bhowruth V, Veerapen N, Besra GS, Kasmar A, Peng W, Moody DB, Grabowski GA, Brenner MB.
Proc Natl Acad Sci U S A 2012-03-20
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Spatial organization of the mouse genome and its role in recurrent chromosomal translocations.

Authors: Authors: Zhang Y, McCord RP, Ho YJ, Lajoie BR, Hildebrand DG, Simon AC, Becker MS, Alt FW, Dekker J.
Cell 2012-03-02
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Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair.

Authors: Authors: Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C.
Proc Natl Acad Sci U S A 2012-02-14
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Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).

Authors: Authors: Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B.
Proc Natl Acad Sci U S A 2012-02-14
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Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks.

Authors: Authors: Boboila C, Alt FW, Schwer B.
Adv Immunol 2012-01-01
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Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281.

Authors: Authors: Yancopoulos GD, Alt FW.
J Immunol 2012-01-01
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Structural elucidation of diglycosyl diacylglycerol and monoglycosyl diacylglycerol from Streptococcus pneumoniae by multiple-stage linear ion-trap mass spectrometry with electrospray ionization.

Authors: Authors: Tatituri RV, Brenner MB, Turk J, Hsu FF.
J Mass Spectrom 2012-01-01
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Immature B cells preferentially switch to IgE with increased direct Sµ to Se recombination.

Authors: Authors: Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW.
J Exp Med 2011-12-19
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