Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Spatial organization of the mouse genome and its role in recurrent chromosomal translocations.

Authors: Authors: Zhang Y, McCord RP, Ho YJ, Lajoie BR, Hildebrand DG, Simon AC, Becker MS, Alt FW, Dekker J.
Cell 2012-03-02
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Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).

Authors: Authors: Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B.
Proc Natl Acad Sci U S A 2012-02-14
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Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair.

Authors: Authors: Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C.
Proc Natl Acad Sci U S A 2012-02-14
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Structural elucidation of diglycosyl diacylglycerol and monoglycosyl diacylglycerol from Streptococcus pneumoniae by multiple-stage linear ion-trap mass spectrometry with electrospray ionization.

Authors: Authors: Tatituri RV, Brenner MB, Turk J, Hsu FF.
J Mass Spectrom 2012-01-01
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Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks.

Authors: Authors: Boboila C, Alt FW, Schwer B.
Adv Immunol 2012-01-01
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Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281.

Authors: Authors: Yancopoulos GD, Alt FW.
J Immunol 2012-01-01
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Immature B cells preferentially switch to IgE with increased direct Sµ to Se recombination.

Authors: Authors: Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW.
J Exp Med 2011-12-19
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Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement.

Authors: Authors: Noss EH, Chang SK, Watts GF, Brenner MB.
Arthritis Rheum 2011-12-01
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Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner.

Authors: Authors: King IL, Fortier A, Tighe M, Dibble J, Watts GF, Veerapen N, Haberman AM, Besra GS, Mohrs M, Brenner MB, Leadbetter EA.
Nat Immunol 2011-11-27
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Innate recognition of cell wall ß-glucans drives invariant natural killer T cell responses against fungi.

Authors: Authors: Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levitz SM, Brigl M, Brenner MB.
2011-11-17
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