Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CTCF-binding elements mediate control of V(D)J recombination.

Authors: Authors: Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, Schlissel MS, Murre C, Busslinger M, Giallourakis CC, Alt FW.
Nature 2011-09-11
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Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.

Authors: Authors: Garg S, Sharma M, Ung C, Tuli A, Barral DC, Hava DL, Veerapen N, Besra GS, Hacohen N, Brenner MB.
Immunity 2011-08-26
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Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.

Authors: Authors: Jeevan-Raj BP, Robert I, Heyer V, Page A, Wang JH, Cammas F, Alt FW, Losson R, Reina-San-Martin B.
J Exp Med 2011-08-01
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Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.

Authors: Authors: Brigl M, Tatituri RV, Watts GF, Bhowruth V, Leadbetter EA, Barton N, Cohen NR, Hsu FF, Besra GS, Brenner MB.
J Exp Med 2011-06-06
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The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.

Authors: Authors: Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM.
Nat Immunol 2011-06-01
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Cadherin-11 regulates fibroblast inflammation.

Authors: Authors: Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB.
Proc Natl Acad Sci U S A 2011-05-17
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Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency.

Authors: Authors: Rucci F, Poliani PL, Caraffi S, Paganini T, Fontana E, Giliani S, Alt FW, Notarangelo LD.
Front Immunol 2011-05-10
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Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration.

Authors: Authors: Gu Z, Noss EH, Hsu VW, Brenner MB.
J Cell Biol 2011-04-04
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PAIRing for distal Igh locus V(D)J recombination.

Authors: Authors: Guo C, Alt FW, Giallourakis C.
Immunity 2011-02-25
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Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.

Authors: Authors: Eccleston J, Yan C, Yuan K, Alt FW, Selsing E.
J Immunol 2011-02-15
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