Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals.

Authors: Authors: Brennan PJ, Tatituri RV, Brigl M, Kim EY, Tuli A, Sanderson JP, Gadola SD, Hsu FF, Besra GS, Brenner MB.
Nat Immunol 2011-10-30
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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.

Authors: Authors: Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E.
Mol Cell 2011-10-21
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The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.

Authors: Authors: Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT.
Blood 2011-10-13
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Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

Authors: Authors: Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC, Gostissa M, Alt FW.
Cell 2011-09-30
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CTCF-binding elements mediate control of V(D)J recombination.

Authors: Authors: Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, Schlissel MS, Murre C, Busslinger M, Giallourakis CC, Alt FW.
Nature 2011-09-11
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Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.

Authors: Authors: Garg S, Sharma M, Ung C, Tuli A, Barral DC, Hava DL, Veerapen N, Besra GS, Hacohen N, Brenner MB.
Immunity 2011-08-26
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Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.

Authors: Authors: Jeevan-Raj BP, Robert I, Heyer V, Page A, Wang JH, Cammas F, Alt FW, Losson R, Reina-San-Martin B.
J Exp Med 2011-08-01
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Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.

Authors: Authors: Brigl M, Tatituri RV, Watts GF, Bhowruth V, Leadbetter EA, Barton N, Cohen NR, Hsu FF, Besra GS, Brenner MB.
J Exp Med 2011-06-06
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The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.

Authors: Authors: Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM.
Nat Immunol 2011-06-01
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Cadherin-11 regulates fibroblast inflammation.

Authors: Authors: Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB.
Proc Natl Acad Sci U S A 2011-05-17
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