Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.

Authors: Authors: Eccleston J, Yan C, Yuan K, Alt FW, Selsing E.
J Immunol 2011-02-15
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The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.

Authors: Authors: Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW.
Cell 2011-02-04
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Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.

Authors: Authors: Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW.
Proc Natl Acad Sci U S A 2011-02-01
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ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.

Authors: Authors: Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW.
Nature 2011-01-13
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Mechanisms that promote and suppress chromosomal translocations in lymphocytes.

Authors: Authors: Gostissa M, Alt FW, Chiarle R.
Annu Rev Immunol 2011-01-01
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Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.

Authors: Authors: Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW.
Proc Natl Acad Sci U S A 2010-12-21
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Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.

Authors: Authors: Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW.
Proc Natl Acad Sci U S A 2010-12-14
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SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

Authors: Authors: Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E.
Cell Metab 2010-12-01
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Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.

Authors: Authors: Perlot T, Pawlitzky I, Manis JP, Zarrin AA, Brodeur PH, Alt FW.
PLoS One 2010-11-15
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Hypomorphic Rag mutations can cause destructive midline granulomatous disease.

Authors: Authors: De Ravin SS, Cowen EW, Zarember KA, Whiting-Theobald NL, Kuhns DB, Sandler NG, Douek DC, Pittaluga S, Poliani PL, Lee YN, Notarangelo LD, Wang L, Alt FW, Kang EM, Milner JD, Niemela JE, Fontana-Penn M, Sinal SH, Malech HL.
Blood 2010-08-26
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