Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency.

Authors: Authors: Rucci F, Poliani PL, Caraffi S, Paganini T, Fontana E, Giliani S, Alt FW, Notarangelo LD.
Front Immunol 2011-05-10
View full abstract on Pubmed

Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration.

Authors: Authors: Gu Z, Noss EH, Hsu VW, Brenner MB.
J Cell Biol 2011-04-04
View full abstract on Pubmed

PAIRing for distal Igh locus V(D)J recombination.

Authors: Authors: Guo C, Alt FW, Giallourakis C.
Immunity 2011-02-25
View full abstract on Pubmed

Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.

Authors: Authors: Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP.
Proc Natl Acad Sci U S A 2011-02-15
View full abstract on Pubmed

Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.

Authors: Authors: Eccleston J, Yan C, Yuan K, Alt FW, Selsing E.
J Immunol 2011-02-15
View full abstract on Pubmed

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.

Authors: Authors: Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW.
Cell 2011-02-04
View full abstract on Pubmed

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.

Authors: Authors: Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW.
Proc Natl Acad Sci U S A 2011-02-01
View full abstract on Pubmed

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.

Authors: Authors: Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW.
Nature 2011-01-13
View full abstract on Pubmed

Mechanisms that promote and suppress chromosomal translocations in lymphocytes.

Authors: Authors: Gostissa M, Alt FW, Chiarle R.
Annu Rev Immunol 2011-01-01
View full abstract on Pubmed

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.

Authors: Authors: Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW.
Proc Natl Acad Sci U S A 2010-12-21
View full abstract on Pubmed