Frederick Alt, Ph.D.
Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
Authors: Authors: Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
Authors: Authors: Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E.
Cell Metab
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Cell Metab
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Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.
Authors: Authors: Perlot T, Pawlitzky I, Manis JP, Zarrin AA, Brodeur PH, Alt FW.
PLoS One
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PLoS One
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Hypomorphic Rag mutations can cause destructive midline granulomatous disease.
Authors: Authors: De Ravin SS, Cowen EW, Zarember KA, Whiting-Theobald NL, Kuhns DB, Sandler NG, Douek DC, Pittaluga S, Poliani PL, Lee YN, Notarangelo LD, Wang L, Alt FW, Kang EM, Milner JD, Niemela JE, Fontana-Penn M, Sinal SH, Malech HL.
Blood
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Blood
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ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
Authors: Authors: Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW.
J Exp Med
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J Exp Med
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Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency.
Authors: Authors: Walter JE, Rucci F, Patrizi L, Recher M, Regenass S, Paganini T, Keszei M, Pessach I, Lang PA, Poliani PL, Giliani S, Al-Herz W, Cowan MJ, Puck JM, Bleesing J, Niehues T, Schuetz C, Malech H, DeRavin SS, Facchetti F, Gennery AR, Andersson E, Kamani NR, Sekiguchi J, Alenezi HM, Chinen J, Dbaibo G, ElGhazali G, Fontana A, Pasic S, Detre C, Terhorst C, Alt FW, Notarangelo LD.
J Exp Med
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J Exp Med
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Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.
Authors: Authors: Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB.
J Exp Med
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J Exp Med
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Synthesis of a novel alpha-galactosyl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies.
Authors: Authors: Veerapen N, Leadbetter EA, Brenner MB, Cox LR, Besra GS.
Bioconjug Chem
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Bioconjug Chem
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Regulation of CD1 antigen-presenting complex stability.
Authors: Authors: Odyniec AN, Barral DC, Garg S, Tatituri RV, Besra GS, Brenner MB.
J Biol Chem
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J Biol Chem
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How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens.