Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
Authors: Authors: Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW.
J Exp Med
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Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency.
Authors: Authors: Walter JE, Rucci F, Patrizi L, Recher M, Regenass S, Paganini T, Keszei M, Pessach I, Lang PA, Poliani PL, Giliani S, Al-Herz W, Cowan MJ, Puck JM, Bleesing J, Niehues T, Schuetz C, Malech H, DeRavin SS, Facchetti F, Gennery AR, Andersson E, Kamani NR, Sekiguchi J, Alenezi HM, Chinen J, Dbaibo G, ElGhazali G, Fontana A, Pasic S, Detre C, Terhorst C, Alt FW, Notarangelo LD.
J Exp Med
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Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.
Authors: Authors: Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB.
J Exp Med
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Synthesis of a novel alpha-galactosyl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies.
Authors: Authors: Veerapen N, Leadbetter EA, Brenner MB, Cox LR, Besra GS.
Bioconjug Chem
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Regulation of CD1 antigen-presenting complex stability.
Authors: Authors: Odyniec AN, Barral DC, Garg S, Tatituri RV, Besra GS, Brenner MB.
J Biol Chem
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How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens.
Authors: Authors: Brigl M, Brenner MB.
Semin Immunol
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Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450. 1989.
Authors: Authors: Porcelli S, Brenner MB, Greenstein JL, Terhorst C, Balk SP, Bleicher PA.
J Immunol
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Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected].
Authors: Authors: Muindi K, Cernadas M, Watts GF, Royle L, Neville DC, Dwek RA, Besra GS, Rudd PM, Butters TD, Brenner MB.
Proc Natl Acad Sci U S A
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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Authors: Authors: Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E.
Nature
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Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens.
Authors: Authors: Cernadas M, Cavallari M, Watts G, Mori L, De Libero G, Brenner MB.
J Immunol
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