Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.
Authors: Authors: Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM.
Arthritis Rheum
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Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.
Authors: Authors: Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, Recher M, Andersson EM, Zha S, Giliani S, Terhorst C, Alt FW, Yan CT.
Proc Natl Acad Sci U S A
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Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.
Authors: Authors: Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW.
Proc Natl Acad Sci U S A
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Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.
Authors: Authors: Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW.
Proc Natl Acad Sci U S A
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Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.
Authors: Authors: Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW.
J Exp Med
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The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.
Authors: Authors: Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW.
Adv Immunol
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Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector.
Authors: Authors: Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G.
Stem Cells
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Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11.
Authors: Authors: Chang SK, Gu Z, Brenner MB.
Immunol Rev
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Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.
Authors: Authors: Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW.
Nature
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Rapid and reliable generation of invariant natural killer T-cell lines in vitro.
Authors: Authors: Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB.
Immunology
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