Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.
Authors: Authors: Felio K, Nguyen H, Dascher CC, Choi HJ, Li S, Zimmer MI, Colmone A, Moody DB, Brenner MB, Wang CR.
J Exp Med
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Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility.
Authors: Authors: Lee YN, Alt FW, Reyes J, Gleason M, Zarrin AA, Jung D.
Proc Natl Acad Sci U S A
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Calorie restriction alters mitochondrial protein acetylation.
Authors: Authors: Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB.
Aging Cell
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Mre11: roles in DNA repair beyond homologous recombination.
Authors: Authors: Zha S, Boboila C, Alt FW.
Nat Struct Mol Biol
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T cell responses in microbial infection.
Authors: Authors: Modlin RL, Brenner MB.
Curr Opin Immunol
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Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.
Authors: Authors: Veerapen N, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS.
Bioorg Med Chem Lett
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Mechanisms promoting translocations in editing and switching peripheral B cells.
Authors: Authors: Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.
Nature
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CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.
Authors: Authors: Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, Barral D, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB.
J Exp Med
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Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.
Authors: Authors: Basu U, Franklin A, Schwer B, Cheng HL, Chaudhuri J, Alt FW.
Biochem Soc Trans
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Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
Authors: Authors: Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M.
Mol Cell
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