Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector.

Authors: Authors: Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G.
Stem Cells 2010-01-01
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Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11.

Authors: Authors: Chang SK, Gu Z, Brenner MB.
Immunol Rev 2010-01-01
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Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.

Authors: Authors: Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW.
Nature 2009-12-10
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Rapid and reliable generation of invariant natural killer T-cell lines in vitro.

Authors: Authors: Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB.
Immunology 2009-11-01
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CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.

Authors: Authors: Felio K, Nguyen H, Dascher CC, Choi HJ, Li S, Zimmer MI, Colmone A, Moody DB, Brenner MB, Wang CR.
J Exp Med 2009-10-26
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Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility.

Authors: Authors: Lee YN, Alt FW, Reyes J, Gleason M, Zarrin AA, Jung D.
Proc Natl Acad Sci U S A 2009-10-13
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Calorie restriction alters mitochondrial protein acetylation.

Authors: Authors: Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB.
Aging Cell 2009-09-01
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T cell responses in microbial infection.

Authors: Authors: Modlin RL, Brenner MB.
Curr Opin Immunol 2009-08-01
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Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.

Authors: Authors: Veerapen N, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS.
Bioorg Med Chem Lett 2009-08-01
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Mre11: roles in DNA repair beyond homologous recombination.

Authors: Authors: Zha S, Boboila C, Alt FW.
Nat Struct Mol Biol 2009-08-01
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