Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.

Authors: Authors: Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, Recher M, Andersson EM, Zha S, Giliani S, Terhorst C, Alt FW, Yan CT.
Proc Natl Acad Sci U S A 2010-02-16
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Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.

Authors: Authors: Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW.
J Exp Med 2010-02-15
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The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.

Authors: Authors: Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW.
Adv Immunol 2010-01-01
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Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector.

Authors: Authors: Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G.
Stem Cells 2010-01-01
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Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11.

Authors: Authors: Chang SK, Gu Z, Brenner MB.
Immunol Rev 2010-01-01
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Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.

Authors: Authors: Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW.
Nature 2009-12-10
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Rapid and reliable generation of invariant natural killer T-cell lines in vitro.

Authors: Authors: Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB.
Immunology 2009-11-01
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CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.

Authors: Authors: Felio K, Nguyen H, Dascher CC, Choi HJ, Li S, Zimmer MI, Colmone A, Moody DB, Brenner MB, Wang CR.
J Exp Med 2009-10-26
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Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility.

Authors: Authors: Lee YN, Alt FW, Reyes J, Gleason M, Zarrin AA, Jung D.
Proc Natl Acad Sci U S A 2009-10-13
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Calorie restriction alters mitochondrial protein acetylation.

Authors: Authors: Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB.
Aging Cell 2009-09-01
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