Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation.

Authors: Authors: Chakraborty T, Perlot T, Subrahmanyam R, Jani A, Goff PH, Zhang Y, Ivanova I, Alt FW, Sen R.
J Exp Med 2009-05-11
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Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes.

Authors: Authors: Kiener HP, Niederreiter B, Lee DM, Jimenez-Boj E, Smolen JS, Brenner MB.
Arthritis Rheum 2009-05-01
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Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire.

Authors: Authors: Carpenter AC, Yang-Iott KS, Chao LH, Nuskey B, Whitlow S, Alt FW, Bassing CH.
J Immunol 2009-05-01
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Long-lasting molecular changes in human skin after repetitive in situ UV irradiation.

Authors: Authors: Brenner M, Coelho SG, Beer JZ, Miller SA, Wolber R, Smuda C, Hearing VJ.
J Invest Dermatol 2009-04-01
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Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.

Authors: Authors: Giblin W, Chatterji M, Westfield G, Masud T, Theisen B, Cheng HL, DeVido J, Alt FW, Ferguson DO, Schatz DG, Sekiguchi J.
Blood 2009-03-26
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Post-translational regulation of activation-induced cytidine deaminase.

Authors: Authors: Basu U, Franklin A, Alt FW.
Philos Trans R Soc Lond B Biol Sci 2009-03-12
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CD1a expression defines an interleukin-12 producing population of human dendritic cells.

Authors: Authors: Cernadas M, Lu J, Watts G, Brenner MB.
Clin Exp Immunol 2009-03-01
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Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice.

Authors: Authors: Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, Astarita J, Phan RT, Datta A, Manis J, Alt FW, Chaudhuri J.
Proc Natl Acad Sci U S A 2009-02-24
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Chromosomal location targets different MYC family gene members for oncogenic translocations.

Authors: Authors: Gostissa M, Ranganath S, Bianco JM, Alt FW.
Proc Natl Acad Sci U S A 2009-02-17
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Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.

Authors: Authors: Schenten D, Kracker S, Esposito G, Franco S, Klein U, Murphy M, Alt FW, Rajewsky K.
J Exp Med 2009-02-16
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