Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.
Authors: Authors: Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O.
Nat Med
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Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity.
Authors: Authors: Cohen NR, Garg S, Brenner MB.
Adv Immunol
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Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching.
Authors: Authors: Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT.
J Exp Med
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Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.
Authors: Authors: Sada-Ovalle I, Chiba A, Gonzales A, Brenner MB, Behar SM.
PLoS Pathog
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SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
Authors: Authors: Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.
Cell
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Serum lipids regulate dendritic cell CD1 expression and function.
Authors: Authors: Leslie DS, Dascher CC, Cembrola K, Townes MA, Hava DL, Hugendubler LC, Mueller E, Fox L, Roura-Mir C, Moody DB, Vincent MS, Gumperz JE, Illarionov PA, Besra GS, Reynolds CG, Brenner MB.
Immunology
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Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.
Authors: Authors: Basu U, Wang Y, Alt FW.
Mol Cell
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Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.
Authors: Authors: Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S.
Mol Cell
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AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.
Authors: Authors: Takizawa M, Tolarová H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R.
J Exp Med
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CD1a and MHC class I follow a similar endocytic recycling pathway.
Authors: Authors: Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB.
Traffic
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