Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CD1a and MHC class I follow a similar endocytic recycling pathway.
Authors: Authors: Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB.
Traffic
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Rapid NKT cell responses are self-terminating during the course of microbial infection.
Authors: Authors: Chiba A, Dascher CC, Besra GS, Brenner MB.
J Immunol
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Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation.
Authors: Authors: Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB.
Proc Natl Acad Sci U S A
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Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules.
Authors: Authors: Kaser A, Hava DL, Dougan SK, Chen Z, Zeissig S, Brenner MB, Blumberg RS.
Eur J Immunol
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SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
Authors: Authors: Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, Mostoslavsky R, Alt FW, Schibler U.
Cell
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Complementary functions of ATM and H2AX in development and suppression of genomic instability.
Authors: Authors: Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW.
Proc Natl Acad Sci U S A
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Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.
Authors: Authors: Zarrin AA, Goff PH, Senger K, Alt FW.
J Exp Med
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Tissue-specific regulation of SIRT1 by calorie restriction.
Authors: Authors: Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L.
Genes Dev
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NK T cells provide lipid antigen-specific cognate help for B cells.
Authors: Authors: Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB.
Proc Natl Acad Sci U S A
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Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.
Authors: Authors: Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH.
Genes Dev
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