Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis.
Authors: Authors: Noss EH, Brenner MB.
Immunol Rev
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Coexpression of two mesenchymal cadherins, cadherin 11 and N-cadherin, on murine fibroblast-like synoviocytes.
Authors: Authors: Agarwal SK, Lee DM, Kiener HP, Brenner MB.
Arthritis Rheum
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DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.
Authors: Authors: Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW.
J Exp Med
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Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.
Authors: Authors: Perlot T, Li G, Alt FW.
Proc Natl Acad Sci U S A
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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Authors: Authors: Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T.
Proc Natl Acad Sci U S A
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Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.
Authors: Authors: Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P.
Mol Cell Biol
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Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement.
Authors: Authors: Ranganath S, Carpenter AC, Gleason M, Shaw AC, Bassing CH, Alt FW.
J Immunol
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Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.
Authors: Authors: Bassing CH, Ranganath S, Murphy M, Savic V, Gleason M, Alt FW.
Blood
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SIRT6 in DNA repair, metabolism and ageing.
Authors: Authors: Lombard DB, Schwer B, Alt FW, Mostoslavsky R.
J Intern Med
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Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.
Authors: Authors: Takeyama K, Monti S, Manis JP, Dal Cin P, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA.
Oncogene
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