Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.

Authors: Authors: Zarrin AA, Goff PH, Senger K, Alt FW.
J Exp Med 2008-07-07
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Tissue-specific regulation of SIRT1 by calorie restriction.

Authors: Authors: Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L.
Genes Dev 2008-07-01
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NK T cells provide lipid antigen-specific cognate help for B cells.

Authors: Authors: Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB.
Proc Natl Acad Sci U S A 2008-06-17
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Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.

Authors: Authors: Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH.
Genes Dev 2008-06-15
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The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis.

Authors: Authors: Noss EH, Brenner MB.
Immunol Rev 2008-06-01
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Coexpression of two mesenchymal cadherins, cadherin 11 and N-cadherin, on murine fibroblast-like synoviocytes.

Authors: Authors: Agarwal SK, Lee DM, Kiener HP, Brenner MB.
Arthritis Rheum 2008-04-01
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DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.

Authors: Authors: Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW.
J Exp Med 2008-03-17
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Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.

Authors: Authors: Perlot T, Li G, Alt FW.
Proc Natl Acad Sci U S A 2008-03-11
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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.

Authors: Authors: Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T.
Proc Natl Acad Sci U S A 2008-03-04
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Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.

Authors: Authors: Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P.
Mol Cell Biol 2008-03-01
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