Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement.

Authors: Authors: Ranganath S, Carpenter AC, Gleason M, Shaw AC, Bassing CH, Alt FW.
J Immunol 2008-02-15
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Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.

Authors: Authors: Bassing CH, Ranganath S, Murphy M, Savic V, Gleason M, Alt FW.
Blood 2008-02-15
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SIRT6 in DNA repair, metabolism and ageing.

Authors: Authors: Lombard DB, Schwer B, Alt FW, Mostoslavsky R.
J Intern Med 2008-02-01
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Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.

Authors: Authors: Takeyama K, Monti S, Manis JP, Dal Cin P, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA.
Oncogene 2008-01-10
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Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.

Authors: Authors: Perlot T, Alt FW.
Adv Immunol 2008-01-01
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Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.

Authors: Authors: Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R.
Mol Cell 2007-12-28
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

Authors: Authors: Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B.
Mol Cell Biol 2007-12-01
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CD1 antigen presentation: how it works.

Authors: Authors: Barral DC, Brenner MB.
Nat Rev Immunol 2007-12-01
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From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology.

Authors: Authors: Alt FW.
Eur J Immunol 2007-11-01
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S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.

Authors: Authors: Wuerffel R, Wang L, Grigera F, Manis J, Selsing E, Perlot T, Alt FW, Cogne M, Pinaud E, Kenter AL.
Immunity 2007-11-01
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