Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.

Authors: Authors: Perlot T, Alt FW.
Adv Immunol 2008-01-01
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Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.

Authors: Authors: Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R.
Mol Cell 2007-12-28
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CD1 antigen presentation: how it works.

Authors: Authors: Barral DC, Brenner MB.
Nat Rev Immunol 2007-12-01
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

Authors: Authors: Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B.
Mol Cell Biol 2007-12-01
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From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology.

Authors: Authors: Alt FW.
Eur J Immunol 2007-11-01
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S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.

Authors: Authors: Wuerffel R, Wang L, Grigera F, Manis J, Selsing E, Perlot T, Alt FW, Cogne M, Pinaud E, Kenter AL.
Immunity 2007-11-01
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The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.

Authors: Authors: Parisini E, Higgins JM, Liu JH, Brenner MB, Wang JH.
J Mol Biol 2007-10-19
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SIRT1 controls endothelial angiogenic functions during vascular growth.

Authors: Authors: Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S.
Genes Dev 2007-10-15
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IgH class switching and translocations use a robust non-classical end-joining pathway.

Authors: Authors: Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW.
Nature 2007-09-27
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Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

Authors: Authors: Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB.
Proc Natl Acad Sci U S A 2007-09-25
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