Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.

Authors: Authors: Parisini E, Higgins JM, Liu JH, Brenner MB, Wang JH.
J Mol Biol 2007-10-19
View full abstract on Pubmed

SIRT1 controls endothelial angiogenic functions during vascular growth.

Authors: Authors: Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S.
Genes Dev 2007-10-15
View full abstract on Pubmed

IgH class switching and translocations use a robust non-classical end-joining pathway.

Authors: Authors: Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW.
Nature 2007-09-27
View full abstract on Pubmed

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

Authors: Authors: Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB.
Proc Natl Acad Sci U S A 2007-09-25
View full abstract on Pubmed

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.

Authors: Authors: Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y.
Nat Immunol 2007-07-01
View full abstract on Pubmed

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.

Authors: Authors: Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P.
EMBO J 2007-04-04
View full abstract on Pubmed

Cadherin-11 in synovial lining formation and pathology in arthritis.

Authors: Authors: Lee DM, Kiener HP, Agarwal SK, Noss EH, Watts GF, Chisaka O, Takeichi M, Brenner MB.
Science 2007-03-16
View full abstract on Pubmed

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.

Authors: Authors: Zha S, Alt FW, Cheng HL, Brush JW, Li G.
Proc Natl Acad Sci U S A 2007-03-13
View full abstract on Pubmed

Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.

Authors: Authors: Wu C, Ranganath S, Gleason M, Woodman BB, Borjeson TM, Alt FW, Bassing CH.
Proc Natl Acad Sci U S A 2007-03-06
View full abstract on Pubmed

Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

Authors: Authors: Zarrin AA, Del Vecchio C, Tseng E, Gleason M, Zarin P, Tian M, Alt FW.
Science 2007-01-19
View full abstract on Pubmed