Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.

Authors: Authors: Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y.
Nat Immunol 2007-07-01
View full abstract on Pubmed

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.

Authors: Authors: Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P.
EMBO J 2007-04-04
View full abstract on Pubmed

Cadherin-11 in synovial lining formation and pathology in arthritis.

Authors: Authors: Lee DM, Kiener HP, Agarwal SK, Noss EH, Watts GF, Chisaka O, Takeichi M, Brenner MB.
Science 2007-03-16
View full abstract on Pubmed

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.

Authors: Authors: Zha S, Alt FW, Cheng HL, Brush JW, Li G.
Proc Natl Acad Sci U S A 2007-03-13
View full abstract on Pubmed

Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.

Authors: Authors: Wu C, Ranganath S, Gleason M, Woodman BB, Borjeson TM, Alt FW, Bassing CH.
Proc Natl Acad Sci U S A 2007-03-06
View full abstract on Pubmed

Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

Authors: Authors: Zarrin AA, Del Vecchio C, Tseng E, Gleason M, Zarin P, Tian M, Alt FW.
Science 2007-01-19
View full abstract on Pubmed

Evolution of the immunoglobulin heavy chain class switch recombination mechanism.

Authors: Authors: Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW.
Adv Immunol 2007-01-01
View full abstract on Pubmed

Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading, and presentation.

Authors: Authors: Sugita M, Barral DC, Brenner MB.
Curr Top Microbiol Immunol 2007-01-01
View full abstract on Pubmed

Regulation of activation induced deaminase via phosphorylation.

Authors: Authors: Basu U, Chaudhuri J, Phan RT, Datta A, Alt FW.
Adv Exp Med Biol 2007-01-01
View full abstract on Pubmed

Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer.

Authors: Authors: Mostoslavsky G, Fabian AJ, Rooney S, Alt FW, Mulligan RC.
Proc Natl Acad Sci U S A 2006-10-31
View full abstract on Pubmed