Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CD1 antigen presentation: how it works.
Authors: Authors: Barral DC, Brenner MB.
Nat Rev Immunol
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From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology.
Authors: Authors: Alt FW.
Eur J Immunol
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S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.
Authors: Authors: Wuerffel R, Wang L, Grigera F, Manis J, Selsing E, Perlot T, Alt FW, Cogne M, Pinaud E, Kenter AL.
Immunity
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The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.
Authors: Authors: Parisini E, Higgins JM, Liu JH, Brenner MB, Wang JH.
J Mol Biol
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SIRT1 controls endothelial angiogenic functions during vascular growth.
Authors: Authors: Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S.
Genes Dev
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IgH class switching and translocations use a robust non-classical end-joining pathway.
Authors: Authors: Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW.
Nature
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Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.
Authors: Authors: Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB.
Proc Natl Acad Sci U S A
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Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.
Authors: Authors: Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y.
Nat Immunol
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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.
Authors: Authors: Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P.
EMBO J
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Cadherin-11 in synovial lining formation and pathology in arthritis.
Authors: Authors: Lee DM, Kiener HP, Agarwal SK, Noss EH, Watts GF, Chisaka O, Takeichi M, Brenner MB.
Science
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