Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.

Authors: Authors: Shen RR, Ferguson DO, Renard M, Hoyer KK, Kim U, Hao X, Alt FW, Roeder RG, Morse HC, Teitell MA.
Blood 2006-09-15
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SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

Authors: Authors: Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L.
Cell 2006-09-08
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Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations.

Authors: Authors: Franco S, Alt FW, Manis JP.
DNA Repair (Amst) 2006-09-08
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The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells.

Authors: Authors: Aifantis I, Bassing CH, Garbe AI, Sawai K, Alt FW, von Boehmer H.
J Exp Med 2006-06-12
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SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis.

Authors: Authors: Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R, Reinberg D.
Genes Dev 2006-05-15
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XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.

Authors: Authors: Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW.
Proc Natl Acad Sci U S A 2006-05-09
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The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility.

Authors: Authors: Kiener HP, Stipp CS, Allen PG, Higgins JM, Brenner MB.
Mol Biol Cell 2006-05-01
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Early embryonic lethality due to targeted inactivation of DNA ligase III.

Authors: Authors: Puebla-Osorio N, Lacey DB, Alt FW, Zhu C.
Mol Cell Biol 2006-05-01
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Role of adhesion molecules in synovial inflammation.

Authors: Authors: Agarwal SK, Brenner MB.
Curr Opin Rheumatol 2006-05-01
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Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro.

Authors: Authors: Kiener HP, Lee DM, Agarwal SK, Brenner MB.
Am J Pathol 2006-05-01
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