Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Regulation of activation induced deaminase via phosphorylation.

Authors: Authors: Basu U, Chaudhuri J, Phan RT, Datta A, Alt FW.
Adv Exp Med Biol 2007-01-01
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Evolution of the immunoglobulin heavy chain class switch recombination mechanism.

Authors: Authors: Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW.
Adv Immunol 2007-01-01
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Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading, and presentation.

Authors: Authors: Sugita M, Barral DC, Brenner MB.
Curr Top Microbiol Immunol 2007-01-01
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Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer.

Authors: Authors: Mostoslavsky G, Fabian AJ, Rooney S, Alt FW, Mulligan RC.
Proc Natl Acad Sci U S A 2006-10-31
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Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.

Authors: Authors: Shen RR, Ferguson DO, Renard M, Hoyer KK, Kim U, Hao X, Alt FW, Roeder RG, Morse HC, Teitell MA.
Blood 2006-09-15
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SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

Authors: Authors: Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L.
Cell 2006-09-08
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Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations.

Authors: Authors: Franco S, Alt FW, Manis JP.
DNA Repair (Amst) 2006-09-08
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The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells.

Authors: Authors: Aifantis I, Bassing CH, Garbe AI, Sawai K, Alt FW, von Boehmer H.
J Exp Med 2006-06-12
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SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis.

Authors: Authors: Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R, Reinberg D.
Genes Dev 2006-05-15
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XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.

Authors: Authors: Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW.
Proc Natl Acad Sci U S A 2006-05-09
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