Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

AID in somatic hypermutation and class switch recombination.

Authors: Authors: Longerich S, Basu U, Alt F, Storb U.
Curr Opin Immunol 2006-04-01
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Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors.

Authors: Authors: Brigl M, van den Elzen P, Chen X, Meyers JH, Wu D, Wong CH, Reddington F, Illarianov PA, Besra GS, Brenner MB, Gumperz JE.
J Immunol 2006-03-15
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53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.

Authors: Authors: Morales JC, Franco S, Murphy MM, Bassing CH, Mills KD, Adams MM, Walsh NC, Manis JP, Rassidakis GZ, Alt FW, Carpenter PB.
Proc Natl Acad Sci U S A 2006-02-28
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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors: Authors: Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW.
Cell 2006-01-27
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H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

Authors: Authors: Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.
Mol Cell 2006-01-20
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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

Authors: Authors: Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J.
Mol Cell 2006-01-20
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Activating Notch1 mutations in mouse models of T-ALL.

Authors: Authors: O'Neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, Alt FW, Kelliher M, Look AT.
Blood 2006-01-15
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Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.

Authors: Authors: Jung D, Giallourakis C, Mostoslavsky R, Alt FW.
Annu Rev Immunol 2006-01-01
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CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium.

Authors: Authors: Bry L, Brigl M, Brenner MB.
Infect Immun 2006-01-01
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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.

Authors: Authors: Basu U, Chaudhuri J, Alpert C, Dutt S, Ranganath S, Li G, Schrum JP, Manis JP, Alt FW.
Nature 2005-11-24
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