Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Activating Notch1 mutations in mouse models of T-ALL.
Authors: Authors: O'Neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, Alt FW, Kelliher M, Look AT.
Blood
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CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium.
Authors: Authors: Bry L, Brigl M, Brenner MB.
Infect Immun
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Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.
Authors: Authors: Jung D, Giallourakis C, Mostoslavsky R, Alt FW.
Annu Rev Immunol
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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
Authors: Authors: Basu U, Chaudhuri J, Alpert C, Dutt S, Ranganath S, Li G, Schrum JP, Manis JP, Alt FW.
Nature
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CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.
Authors: Authors: Vincent MS, Xiong X, Grant EP, Peng W, Brenner MB.
J Immunol
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A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function.
Authors: Authors: Schelonka RL, Ivanov II, Jung DH, Ippolito GC, Nitschke L, Zhuang Y, Gartland GL, Pelkonen J, Alt FW, Rajewsky K, Schroeder HW.
J Immunol
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Apolipoprotein-mediated pathways of lipid antigen presentation.
Authors: Authors: van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB.
Nature
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Elucidation of IgH intronic enhancer functions via germ-line deletion.
Authors: Authors: Perlot T, Alt FW, Bassing CH, Suh H, Pinaud E.
Proc Natl Acad Sci U S A
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Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.
Authors: Authors: Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW.
Cell Metab
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Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family.
Authors: Authors: Miller MM, Wang C, Parisini E, Coletta RD, Goto RM, Lee SY, Barral DC, Townes M, Roura-Mir C, Ford HL, Brenner MB, Dascher CC.
Proc Natl Acad Sci U S A
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