Frederick Alt, Ph.D.
Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.
CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.
Authors: Authors: Vincent MS, Xiong X, Grant EP, Peng W, Brenner MB.
J Immunol
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J Immunol
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A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function.
Authors: Authors: Schelonka RL, Ivanov II, Jung DH, Ippolito GC, Nitschke L, Zhuang Y, Gartland GL, Pelkonen J, Alt FW, Rajewsky K, Schroeder HW.
J Immunol
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J Immunol
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Apolipoprotein-mediated pathways of lipid antigen presentation.
Authors: Authors: van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB.
Nature
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Nature
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Elucidation of IgH intronic enhancer functions via germ-line deletion.
Authors: Authors: Perlot T, Alt FW, Bassing CH, Suh H, Pinaud E.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.
Authors: Authors: Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW.
Cell Metab
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Cell Metab
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Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family.
Authors: Authors: Miller MM, Wang C, Parisini E, Coletta RD, Goto RM, Lee SY, Barral DC, Townes M, Roura-Mir C, Ford HL, Brenner MB, Dascher CC.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo.
Authors: Authors: Snapper SB, Meelu P, Nguyen D, Stockton BM, Bozza P, Alt FW, Rosen FS, von Andrian UH, Klein C.
J Leukoc Biol
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J Leukoc Biol
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Subcellular localization of mycobacteria in tissues and detection of lipid antigens in organelles using cryo-techniques for light and electron microscopy.
Authors: Authors: van der Wel NN, Fluitsma DM, Dascher CC, Brenner MB, Peters PJ.
Curr Opin Microbiol
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Curr Opin Microbiol
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Manifestations of inflammatory arthritis are critically dependent on LFA-1.
Authors: Authors: Watts GM, Beurskens FJ, Martin-Padura I, Ballantyne CM, Klickstein LB, Brenner MB, Lee DM.
J Immunol
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J Immunol
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Molecular mechanism of lipopeptide presentation by CD1a.
Authors: Authors: Zajonc DM, Crispin MD, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, Brenner MB, Moody DB, Wilson IA.
Immunity
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Immunity
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