Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Subcellular localization of mycobacteria in tissues and detection of lipid antigens in organelles using cryo-techniques for light and electron microscopy.
Authors: Authors: van der Wel NN, Fluitsma DM, Dascher CC, Brenner MB, Peters PJ.
Curr Opin Microbiol
View full abstract on Pubmed
WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo.
Authors: Authors: Snapper SB, Meelu P, Nguyen D, Stockton BM, Bozza P, Alt FW, Rosen FS, von Andrian UH, Klein C.
J Leukoc Biol
View full abstract on Pubmed
Manifestations of inflammatory arthritis are critically dependent on LFA-1.
Authors: Authors: Watts GM, Beurskens FJ, Martin-Padura I, Ballantyne CM, Klickstein LB, Brenner MB, Lee DM.
J Immunol
View full abstract on Pubmed
CD1 assembly and the formation of CD1-antigen complexes.
Authors: Authors: Hava DL, Brigl M, van den Elzen P, Zajonc DM, Wilson IA, Brenner MB.
Curr Opin Immunol
View full abstract on Pubmed
Molecular mechanism of lipopeptide presentation by CD1a.
Authors: Authors: Zajonc DM, Crispin MD, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, Brenner MB, Moody DB, Wilson IA.
Immunity
View full abstract on Pubmed
DNA repair, genome stability, and aging.
Authors: Authors: Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW.
Cell
View full abstract on Pubmed
Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.
Authors: Authors: Rooney S, Alt FW, Sekiguchi J, Manis JP.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Influence of switch region length on immunoglobulin class switch recombination.
Authors: Authors: Zarrin AA, Tian M, Wang J, Borjeson T, Alt FW.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.
Authors: Authors: Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y.
Mol Cell Biol
View full abstract on Pubmed
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences.
Authors: Authors: Dudley DD, Chaudhuri J, Bassing CH, Alt FW.
Adv Immunol
View full abstract on Pubmed