Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.

Authors: Authors: Rooney S, Alt FW, Sekiguchi J, Manis JP.
Proc Natl Acad Sci U S A 2005-02-15
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Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.

Authors: Authors: Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y.
Mol Cell Biol 2005-01-01
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Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences.

Authors: Authors: Dudley DD, Chaudhuri J, Bassing CH, Alt FW.
Adv Immunol 2005-01-01
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Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion.

Authors: Authors: Kiener HP, Brenner MB.
Arthritis Res Ther 2005-01-01
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Control of sister chromatid recombination by histone H2AX.

Authors: Authors: Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R.
Mol Cell 2004-12-22
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The role of innate immunity in autoimmunity.

Authors: Authors: Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, Kronenberg M, Lanier LL, Raulet DH, Shlomchik MJ, von Herrath MG.
J Exp Med 2004-12-20
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Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes.

Authors: Authors: Valencia X, Higgins JM, Kiener HP, Lee DM, Podrebarac TA, Dascher CC, Watts GF, Mizoguchi E, Simmons B, Patel DD, Bhan AK, Brenner MB.
J Exp Med 2004-12-20
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Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity.

Authors: Authors: Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A.
Nat Immunol 2004-12-01
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The cellular response to general and programmed DNA double strand breaks.

Authors: Authors: Bassing CH, Alt FW.
DNA Repair (Amst) 2004-12-01
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Antibody diversity: one enzyme to rule them all.

Authors: Authors: Nussenzweig MC, Alt FW.
Nat Med 2004-12-01
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