Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion.
Authors: Authors: Kiener HP, Brenner MB.
Arthritis Res Ther
View full abstract on Pubmed
Control of sister chromatid recombination by histone H2AX.
Authors: Authors: Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R.
Mol Cell
View full abstract on Pubmed
The role of innate immunity in autoimmunity.
Authors: Authors: Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, Kronenberg M, Lanier LL, Raulet DH, Shlomchik MJ, von Herrath MG.
J Exp Med
View full abstract on Pubmed
Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes.
Authors: Authors: Valencia X, Higgins JM, Kiener HP, Lee DM, Podrebarac TA, Dascher CC, Watts GF, Mizoguchi E, Simmons B, Patel DD, Bhan AK, Brenner MB.
J Exp Med
View full abstract on Pubmed
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity.
Authors: Authors: Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A.
Nat Immunol
View full abstract on Pubmed
The cellular response to general and programmed DNA double strand breaks.
Authors: Authors: Bassing CH, Alt FW.
DNA Repair (Amst)
View full abstract on Pubmed
Antibody diversity: one enzyme to rule them all.
Authors: Authors: Nussenzweig MC, Alt FW.
Nat Med
View full abstract on Pubmed
An evolutionarily conserved target motif for immunoglobulin class-switch recombination.
Authors: Authors: Zarrin AA, Alt FW, Chaudhuri J, Stokes N, Kaushal D, Du Pasquier L, Tian M.
Nat Immunol
View full abstract on Pubmed
Identification of guinea pig gammadelta T cells and characterization during pulmonary tuberculosis.
Authors: Authors: Xiong X, Morita CT, Bukowski JF, Brenner MB, Dascher CC.
Vet Immunol Immunopathol
View full abstract on Pubmed
The lingering enigma of the allelic exclusion mechanism.
Authors: Authors: Mostoslavsky R, Alt FW, Rajewsky K.
Cell
View full abstract on Pubmed