Frederick Alt, Ph.D.
Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.
The cellular response to general and programmed DNA double strand breaks.
Antibody diversity: one enzyme to rule them all.
An evolutionarily conserved target motif for immunoglobulin class-switch recombination.
Authors: Authors: Zarrin AA, Alt FW, Chaudhuri J, Stokes N, Kaushal D, Du Pasquier L, Tian M.
Nat Immunol
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Nat Immunol
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Identification of guinea pig gammadelta T cells and characterization during pulmonary tuberculosis.
Authors: Authors: Xiong X, Morita CT, Bukowski JF, Brenner MB, Dascher CC.
Vet Immunol Immunopathol
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Vet Immunol Immunopathol
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The lingering enigma of the allelic exclusion mechanism.
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets.
The role of the non-homologous end-joining pathway in lymphocyte development.
p63 and p73 are not required for the development and p53-dependent apoptosis of T cells.
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair.
Mechanisms of Vdelta1 gammadelta T cell activation by microbial components.