Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

V(D)J recombinational accessibility-heading in the opposite direction?

Authors: Authors: Giallourakis C, Alt FW, Bassing CH.
Nat Immunol 2004-06-01
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Mechanisms of Vdelta1 gammadelta T cell activation by microbial components.

Authors: Authors: Das H, Sugita M, Brenner MB.
J Immunol 2004-06-01
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Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells.

Authors: Authors: Couëdel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M.
Genes Dev 2004-06-01
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Receptor revision in T cells: an open question?

Authors: Authors: Mostoslavsky R, Alt FW.
Trends Immunol 2004-06-01
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Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.

Authors: Authors: Mills KD, Ferguson DO, Essers J, Eckersdorff M, Kanaar R, Alt FW.
Genes Dev 2004-06-01
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53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

Authors: Authors: Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB.
Nat Immunol 2004-05-01
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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Authors: Authors: Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.
Science 2004-03-26
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Molecular biology: case of mistaken identity.

Authors: Authors: Bassing CH, Alt FW.
Nature 2004-03-04
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Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.

Authors: Authors: Dedeoglu F, Horwitz B, Chaudhuri J, Alt FW, Geha RS.
Int Immunol 2004-03-01
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Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation.

Authors: Authors: Tian M, Jones DA, Smith M, Shinkura R, Alt FW.
Mol Cell Biol 2004-03-01
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