Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

New insights into pathways for CD1-mediated antigen presentation.

Authors: Authors: Sugita M, Cernadas M, Brenner MB.
Curr Opin Immunol 2004-03-01
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Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

Authors: Authors: Rooney S, Sekiguchi J, Whitlow S, Eckersdorff M, Manis JP, Lee C, Ferguson DO, Alt FW.
Proc Natl Acad Sci U S A 2004-02-24
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Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF.

Authors: Authors: Tian M, Shinkura R, Shinkura N, Alt FW.
Mol Cell Biol 2004-02-01
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H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity.

Authors: Authors: Bassing CH, Alt FW.
Cell Cycle 2004-02-01
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Unraveling V(D)J recombination; insights into gene regulation.

Authors: Authors: Jung D, Alt FW.
Cell 2004-01-23
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T cell activation by lipopeptide antigens.

Authors: Authors: Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O'Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA, Costello CE, Brenner MB.
Science 2004-01-23
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Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

Authors: Authors: Talukder SR, Dudley DD, Alt FW, Takahama Y, Akamatsu Y.
Nucleic Acids Res 2004-01-01
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Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen.

Authors: Authors: Bry L, Brenner MB.
J Immunol 2004-01-01
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CD1: antigen presentation and T cell function.

Authors: Authors: Brigl M, Brenner MB.
Annu Rev Immunol 2004-01-01
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Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.

Authors: Authors: Brenner MB, Gromada J, Efanov AM, Bokvist K, Mest HJ.
Ann N Y Acad Sci 2003-12-01
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