Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Authors: Authors: Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.
Science 2004-03-26
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Molecular biology: case of mistaken identity.

Authors: Authors: Bassing CH, Alt FW.
Nature 2004-03-04
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Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.

Authors: Authors: Dedeoglu F, Horwitz B, Chaudhuri J, Alt FW, Geha RS.
Int Immunol 2004-03-01
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Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation.

Authors: Authors: Tian M, Jones DA, Smith M, Shinkura R, Alt FW.
Mol Cell Biol 2004-03-01
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New insights into pathways for CD1-mediated antigen presentation.

Authors: Authors: Sugita M, Cernadas M, Brenner MB.
Curr Opin Immunol 2004-03-01
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Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

Authors: Authors: Rooney S, Sekiguchi J, Whitlow S, Eckersdorff M, Manis JP, Lee C, Ferguson DO, Alt FW.
Proc Natl Acad Sci U S A 2004-02-24
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H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity.

Authors: Authors: Bassing CH, Alt FW.
Cell Cycle 2004-02-01
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Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF.

Authors: Authors: Tian M, Shinkura R, Shinkura N, Alt FW.
Mol Cell Biol 2004-02-01
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Unraveling V(D)J recombination; insights into gene regulation.

Authors: Authors: Jung D, Alt FW.
Cell 2004-01-23
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T cell activation by lipopeptide antigens.

Authors: Authors: Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O'Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA, Costello CE, Brenner MB.
Science 2004-01-23
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