Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

The role of chromatin loop extrusion in antibody diversification.

Authors: Authors: Zhang Y, Zhang X, Dai HQ, Hu H, Alt FW.
Nat Rev Immunol 2022-09-01
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SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.

Authors: Authors: Vincendeau E, Wei W, Zhang X, Planchais C, Yu W, Lenden-Hasse H, Cokelaer T, Pipoli da Fonseca J, Mouquet H, Adams DJ, Alt FW, Jackson SP, Balmus G, Lescale C, Deriano L.
Nat Commun 2022-06-28
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C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency.

Authors: Authors: Xie X, Gan T, Rao B, Zhang W, Panchakshari RA, Yang D, Ji X, Cao Y, Alt FW, Meng FL, Hu J.
EMBO J 2022-06-01
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mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.

Authors: Authors: Mu Z, Wiehe K, Saunders KO, Henderson R, Cain DW, Parks R, Martik D, Mansouri K, Edwards RJ, Newman A, Lu X, Xia SM, Eaton A, Bonsignori M, Montefiori D, Han Q, Venkatayogi S, Evangelous T, Wang Y, Rountree W, Korber B, Wagh K, Tam Y, Barbosa C, Alam SM, Williams WB, Tian M, Alt FW, Pardi N, Weissman D, Haynes BF.
Cell Rep 2022-03-15
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SLAMF7 engagement superactivates macrophages in acute and chronic inflammation.

Authors: Authors: Simmons DP, Nguyen HN, Gomez-Rivas E, Jeong Y, Jonsson AH, Chen AF, Lange JK, Dyer GS, Blazar P, Earp BE, Coblyn JS, Massarotti EM, Sparks JA, Todd DJ, Rao DA, Kim EY, Brenner MB.
Sci Immunol 2022-02-11
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Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences.

Authors: Authors: Tarsalainen A, Maman Y, Meng FL, Kyläniemi MK, Soikkeli A, Budzynska P, McDonald JJ, Šenigl F, Alt FW, Schatz DG, Alinikula J.
J Immunol 2022-01-01
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Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination.

Authors: Authors: Oudinet C, Zhang X, Puget N, Kyritsis N, Leduc C, Braikia FZ, Dauba A, Alt FW, Khamlichi AA.
Front Immunol 2022-01-01
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eccDNAs are apoptotic products with high innate immunostimulatory activity.

Authors: Authors: Wang Y, Wang M, Djekidel MN, Chen H, Liu D, Alt FW, Zhang Y.
Nature 2021-11-01
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Fibroblast pathology in inflammatory diseases.

Authors: Authors: Wei K, Nguyen HN, Brenner MB.
J Clin Invest 2021-10-15
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Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons.

Authors: Authors: Cheng YC, Snavely A, Barrett LB, Zhang X, Herman C, Frost DJ, Riva P, Tochitsky I, Kawaguchi R, Singh B, Ivanis J, Huebner EA, Arvanites A, Oza V, Davidow L, Maeda R, Sakuma M, Grantham A, Wang Q, Chang AN, Pfaff K, Costigan M, Coppola G, Rubin LL, Schwer B, Alt FW, Woolf CJ.
Cell Rep 2021-09-07
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