Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Ku70 suppresses alternative end joining in G1-arrested progenitor B cells.

Authors: Authors: Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Alt FW, Frock RL.
Proc Natl Acad Sci U S A 2021-05-25
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An in vivo method for diversifying the functions of therapeutic antibodies.

Authors: Authors: Tian M, Cheng HL, Kimble MT, McGovern K, Waddicor P, Chen Y, Cantor E, Qiu M, Tuchel ME, Dao M, Alt FW.
Proc Natl Acad Sci U S A 2021-03-09
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Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.

Authors: Authors: Chen X, Zhou T, Schmidt SD, Duan H, Cheng C, Chuang GY, Gu Y, Louder MK, Lin BC, Shen CH, Sheng Z, Zheng MX, Doria-Rose NA, Joyce MG, Shapiro L, Tian M, Alt FW, Kwong PD, Mascola JR.
Immunity 2021-02-09
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Loop extrusion mediates physiological Igh locus contraction for RAG scanning.

Authors: Authors: Dai HQ, Hu H, Lou J, Ye AY, Ba Z, Zhang X, Zhang Y, Zhao L, Yoon HS, Chapdelaine-Williams AM, Kyritsis N, Chen H, Johnson K, Lin S, Conte A, Casellas R, Lee CS, Alt FW.
Nature 2021-02-01
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Physiological role of the 3'IgH CBEs super-anchor in antibody class switching.

Authors: Authors: Zhang X, Yoon HS, Chapdelaine-Williams AM, Kyritsis N, Alt FW.
Proc Natl Acad Sci U S A 2021-01-19
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Direct analysis of brain phenotypes via neural blastocyst complementation.

Authors: Authors: Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B.
Nat Protoc 2020-10-01
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CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning.

Authors: Authors: Ba Z, Lou J, Ye AY, Dai HQ, Dring EW, Lin SG, Jain S, Kyritsis N, Kieffer-Kwon KR, Casellas R, Alt FW.
Nature 2020-10-01
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Distinct iNKT Cell Populations Use IFN? or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.

Authors: Authors: LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB.
Cell Metab 2020-08-04
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Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-? in NK cells.

Authors: Authors: Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB.
J Clin Invest 2020-06-01
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Notch signalling drives synovial fibroblast identity and arthritis pathology.

Authors: Authors: Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB.
Nature 2020-06-01
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