Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CD1 and major histocompatibility complex II molecules follow a different course during dendritic cell maturation.

Authors: Authors: van der Wel NN, Sugita M, Fluitsma DM, Cao X, Schreibelt G, Brenner MB, Peters PJ.
Mol Biol Cell 2003-08-01
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WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.

Authors: Authors: Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW.
EMBO J 2003-07-15
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Chromatin dynamics and locus accessibility in the immune system.

Authors: Authors: Mostoslavsky R, Alt FW, Bassing CH.
Nat Immunol 2003-07-01
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Novel antibody switching defects in human patients.

Authors: Authors: Manis JP, Alt FW.
J Clin Invest 2003-07-01
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Cutting edge: major CD8 T cell response to live bacillus Calmette-Guérin is mediated by CD1 molecules.

Authors: Authors: Kawashima T, Norose Y, Watanabe Y, Enomoto Y, Narazaki H, Watari E, Tanaka S, Takahashi H, Yano I, Brenner MB, Sugita M.
J Immunol 2003-06-01
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Understanding the function of CD1-restricted T cells.

Authors: Authors: Vincent MS, Gumperz JE, Brenner MB.
Nat Immunol 2003-06-01
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Deficiencies of GM-CSF and interferon gamma link inflammation and cancer.

Authors: Authors: Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G.
J Exp Med 2003-05-05
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IL-6 production by pulmonary dendritic cells impedes Th1 immune responses.

Authors: Authors: Dodge IL, Carr MW, Cernadas M, Brenner MB.
J Immunol 2003-05-01
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The influence of transcriptional orientation on endogenous switch region function.

Authors: Authors: Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW.
Nat Immunol 2003-05-01
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Transcription-targeted DNA deamination by the AID antibody diversification enzyme.

Authors: Authors: Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW.
Nature 2003-04-17
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