Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Understanding the function of CD1-restricted T cells.

Authors: Authors: Vincent MS, Gumperz JE, Brenner MB.
Nat Immunol 2003-06-01
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Cutting edge: major CD8 T cell response to live bacillus Calmette-Guérin is mediated by CD1 molecules.

Authors: Authors: Kawashima T, Norose Y, Watanabe Y, Enomoto Y, Narazaki H, Watari E, Tanaka S, Takahashi H, Yano I, Brenner MB, Sugita M.
J Immunol 2003-06-01
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Deficiencies of GM-CSF and interferon gamma link inflammation and cancer.

Authors: Authors: Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G.
J Exp Med 2003-05-05
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IL-6 production by pulmonary dendritic cells impedes Th1 immune responses.

Authors: Authors: Dodge IL, Carr MW, Cernadas M, Brenner MB.
J Immunol 2003-05-01
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The influence of transcriptional orientation on endogenous switch region function.

Authors: Authors: Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW.
Nat Immunol 2003-05-01
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Transcription-targeted DNA deamination by the AID antibody diversification enzyme.

Authors: Authors: Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW.
Nature 2003-04-17
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Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice.

Authors: Authors: Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen FS, Alt FW, Mulligan RC, Snapper SB.
Blood 2003-03-15
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T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.

Authors: Authors: Bassing CH, Tillman RE, Woodman BB, Canty D, Monroe RJ, Sleckman BP, Alt FW.
Proc Natl Acad Sci U S A 2003-03-04
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Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.

Authors: Authors: Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J, Fugmann S, Ferguson DO, Schatz DG, Sekiguchi J.
J Exp Med 2003-03-03
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Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission.

Authors: Authors: Araki M, Kondo T, Gumperz JE, Brenner MB, Miyake S, Yamamura T.
Int Immunol 2003-03-01
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