Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.

Authors: Authors: Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA.
Nature 2003-02-06
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Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice.

Authors: Authors: Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA.
Proc Natl Acad Sci U S A 2003-02-04
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Essential role for Vav1 in activation, but not development, of gammadelta T cells.

Authors: Authors: Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW.
Int Immunol 2003-02-01
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Proapoptotic BID is required for myeloid homeostasis and tumor suppression.

Authors: Authors: Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, Kutok JL, Alt FW, Korsmeyer SJ.
Genes Dev 2003-01-15
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Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

Authors: Authors: Jung D, Bassing CH, Fugmann SD, Cheng HL, Schatz DG, Alt FW.
Immunity 2003-01-01
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Elucidation of a downstream boundary of the 3' IgH regulatory region.

Authors: Authors: Manis JP, Michaelson JS, Birshtein BK, Alt FW.
Mol Immunol 2003-01-01
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CD1 antigen presentation and infectious disease.

Authors: Authors: Dascher CC, Brenner MB.
Contrib Microbiol 2003-01-01
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Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300.

Authors: Authors: Barthel R, Tsytsykova AV, Barczak AK, Tsai EY, Dascher CC, Brenner MB, Goldfeld AE.
Mol Cell Biol 2003-01-01
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Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence.

Authors: Authors: Wu C, Bassing CH, Jung D, Woodman BB, Foy D, Alt FW.
Immunity 2003-01-01
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CD1-mediated gamma/delta T cell maturation of dendritic cells.

Authors: Authors: Leslie DS, Vincent MS, Spada FM, Das H, Sugita M, Morita CT, Brenner MB.
J Exp Med 2002-12-16
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