Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice.

Authors: Authors: Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen FS, Alt FW, Mulligan RC, Snapper SB.
Blood 2003-03-15
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T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.

Authors: Authors: Bassing CH, Tillman RE, Woodman BB, Canty D, Monroe RJ, Sleckman BP, Alt FW.
Proc Natl Acad Sci U S A 2003-03-04
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Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.

Authors: Authors: Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J, Fugmann S, Ferguson DO, Schatz DG, Sekiguchi J.
J Exp Med 2003-03-03
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Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission.

Authors: Authors: Araki M, Kondo T, Gumperz JE, Brenner MB, Miyake S, Yamamura T.
Int Immunol 2003-03-01
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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.

Authors: Authors: Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA.
Nature 2003-02-06
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Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice.

Authors: Authors: Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA.
Proc Natl Acad Sci U S A 2003-02-04
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Essential role for Vav1 in activation, but not development, of gammadelta T cells.

Authors: Authors: Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW.
Int Immunol 2003-02-01
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Proapoptotic BID is required for myeloid homeostasis and tumor suppression.

Authors: Authors: Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, Kutok JL, Alt FW, Korsmeyer SJ.
Genes Dev 2003-01-15
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CD1 antigen presentation and infectious disease.

Authors: Authors: Dascher CC, Brenner MB.
Contrib Microbiol 2003-01-01
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Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300.

Authors: Authors: Barthel R, Tsytsykova AV, Barczak AK, Tsai EY, Dascher CC, Brenner MB, Goldfeld AE.
Mol Cell Biol 2003-01-01
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