Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Conservation of CD1 intracellular trafficking patterns between mammalian species.

Authors: Authors: Dascher CC, Hiromatsu K, Xiong X, Sugita M, Buhlmann JE, Dodge IL, Lee SY, Roura-Mir C, Watts GF, Roy CJ, Behar SM, Clemens DL, Porcelli SA, Brenner MB.
J Immunol 2002-12-15
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CD1-dependent dendritic cell instruction.

Authors: Authors: Vincent MS, Leslie DS, Gumperz JE, Xiong X, Grant EP, Brenner MB.
Nat Immunol 2002-12-01
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Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.

Authors: Authors: Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D, Alt FW.
Mol Cell 2002-12-01
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CD1 molecules efficiently present antigen in immature dendritic cells and traffic independently of MHC class II during dendritic cell maturation.

Authors: Authors: Cao X, Sugita M, Van Der Wel N, Lai J, Rogers RA, Peters PJ, Brenner MB.
J Immunol 2002-11-01
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Mast cells: a cellular link between autoantibodies and inflammatory arthritis.

Authors: Authors: Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB.
Science 2002-09-06
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Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation.

Authors: Authors: Yang XF, Ye Q, Press B, Han RZ, Bassing CH, Sleckman BP, Alt FW, Cantor H.
Mol Immunol 2002-09-01
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Internal IgH class switch region deletions are position-independent and enhanced by AID expression.

Authors: Authors: Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW.
Proc Natl Acad Sci U S A 2002-07-23
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Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens.

Authors: Authors: Hiromatsu K, Dascher CC, LeClair KP, Sugita M, Furlong ST, Brenner MB, Porcelli SA.
J Immunol 2002-07-01
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A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells.

Authors: Authors: Solymar DC, Agarwal S, Bassing CH, Alt FW, Rao A.
Immunity 2002-07-01
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T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice.

Authors: Authors: Ye Q, Press B, Kissler S, Yang XF, Lu L, Bassing CH, Sleckman BP, Jansson M, Panoutsakopoulou V, Trimble LA, Alt FW, Cantor H.
J Exp Med 2002-07-01
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