Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence.

Authors: Authors: Wu C, Bassing CH, Jung D, Woodman BB, Foy D, Alt FW.
Immunity 2003-01-01
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Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

Authors: Authors: Jung D, Bassing CH, Fugmann SD, Cheng HL, Schatz DG, Alt FW.
Immunity 2003-01-01
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Elucidation of a downstream boundary of the 3' IgH regulatory region.

Authors: Authors: Manis JP, Michaelson JS, Birshtein BK, Alt FW.
Mol Immunol 2003-01-01
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CD1-mediated gamma/delta T cell maturation of dendritic cells.

Authors: Authors: Leslie DS, Vincent MS, Spada FM, Das H, Sugita M, Morita CT, Brenner MB.
J Exp Med 2002-12-16
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Conservation of CD1 intracellular trafficking patterns between mammalian species.

Authors: Authors: Dascher CC, Hiromatsu K, Xiong X, Sugita M, Buhlmann JE, Dodge IL, Lee SY, Roura-Mir C, Watts GF, Roy CJ, Behar SM, Clemens DL, Porcelli SA, Brenner MB.
J Immunol 2002-12-15
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CD1-dependent dendritic cell instruction.

Authors: Authors: Vincent MS, Leslie DS, Gumperz JE, Xiong X, Grant EP, Brenner MB.
Nat Immunol 2002-12-01
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Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.

Authors: Authors: Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D, Alt FW.
Mol Cell 2002-12-01
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CD1 molecules efficiently present antigen in immature dendritic cells and traffic independently of MHC class II during dendritic cell maturation.

Authors: Authors: Cao X, Sugita M, Van Der Wel N, Lai J, Rogers RA, Peters PJ, Brenner MB.
J Immunol 2002-11-01
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Mast cells: a cellular link between autoantibodies and inflammatory arthritis.

Authors: Authors: Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB.
Science 2002-09-06
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Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation.

Authors: Authors: Yang XF, Ye Q, Press B, Han RZ, Bassing CH, Sleckman BP, Alt FW, Cantor H.
Mol Immunol 2002-09-01
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