Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.
Authors: Authors: Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J, Gao Y, Morton CC, Alt FW.
Cell
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Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.
Authors: Authors: Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW.
Proc Natl Acad Sci U S A
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Characterization of guinea-pig group 1 CD1 proteins.
Authors: Authors: Hiromatsu K, Dascher CC, Sugita M, Gingrich-Baker C, Behar SM, LeClair KP, Brenner MB, Porcelli SA.
Immunology
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The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.
Authors: Authors: Chua KF, Alt FW, Manis JP.
J Exp Med
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Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells.
Authors: Authors: Sugita M, Cao X, Watts GF, Rogers RA, Bonifacino JS, Brenner MB.
Immunity
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Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation.
Authors: Authors: Inlay M, Alt FW, Baltimore D, Xu Y.
Nat Immunol
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Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex.
Authors: Authors: Grant EP, Beckman EM, Behar SM, Degano M, Frederique D, Besra GS, Wilson IA, Porcelli SA, Furlong ST, Brenner MB.
J Immunol
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Vav3 is regulated during the cell cycle and effects cell division.
Authors: Authors: Fujikawa K, Inoue Y, Sakai M, Koyama Y, Nishi S, Funada R, Alt FW, Swat W.
Proc Natl Acad Sci U S A
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IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.
Authors: Authors: Manis JP, Dudley D, Kaylor L, Alt FW.
Immunity
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The mechanism and regulation of chromosomal V(D)J recombination.
Authors: Authors: Bassing CH, Swat W, Alt FW.
Cell
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