Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex.

Authors: Authors: Grant EP, Beckman EM, Behar SM, Degano M, Frederique D, Besra GS, Wilson IA, Porcelli SA, Furlong ST, Brenner MB.
J Immunol 2002-04-15
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Vav3 is regulated during the cell cycle and effects cell division.

Authors: Authors: Fujikawa K, Inoue Y, Sakai M, Koyama Y, Nishi S, Funada R, Alt FW, Swat W.
Proc Natl Acad Sci U S A 2002-04-02
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IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.

Authors: Authors: Manis JP, Dudley D, Kaylor L, Alt FW.
Immunity 2002-04-01
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The mechanism and regulation of chromosomal V(D)J recombination.

Authors: Authors: Bassing CH, Swat W, Alt FW.
Cell 2002-04-01
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Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.

Authors: Authors: Shen Y, Zhou D, Qiu L, Lai X, Simon M, Shen L, Kou Z, Wang Q, Jiang L, Estep J, Hunt R, Clagett M, Sehgal PK, Li Y, Zeng X, Morita CT, Brenner MB, Letvin NL, Chen ZW.
Science 2002-03-22
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Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining.

Authors: Authors: Gumperz JE, Miyake S, Yamamura T, Brenner MB.
J Exp Med 2002-03-04
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Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells.

Authors: Authors: Krawczyk C, Oliveira-dos-Santos A, Sasaki T, Griffiths E, Ohashi PS, Snapper S, Alt F, Penninger JM.
Immunity 2002-03-01
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Cdc42 facilitates invasion but not the actin-based motility of Shigella.

Authors: Authors: Shibata T, Takeshima F, Chen F, Alt FW, Snapper SB.
Curr Biol 2002-02-19
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Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells.

Authors: Authors: Malynn BA, Shaw AC, Young F, Stewart V, Alt FW.
Mol Immunol 2002-01-01
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Mechanism and control of class-switch recombination.

Authors: Authors: Manis JP, Tian M, Alt FW.
Trends Immunol 2002-01-01
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