Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
Authors: Authors: Tsitsikov EN, Laouini D, Dunn IF, Sannikova TY, Davidson L, Alt FW, Geha RS.
Immunity
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DNA double strand break repair and chromosomal translocation: lessons from animal models.
Authors: Authors: Ferguson DO, Alt FW.
Oncogene
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CD1-specific T cells in microbial immunity.
Authors: Authors: Gumperz JE, Brenner MB.
Curr Opin Immunol
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Plasma cell differentiation requires the transcription factor XBP-1.
Authors: Authors: Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH.
Nature
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Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.
Authors: Authors: Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW.
Proc Natl Acad Sci U S A
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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
Authors: Authors: de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW.
Immunity
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Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice.
Authors: Authors: Gärtner F, Alt FW, Monroe RJ, Seidl KJ.
J Exp Med
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T lymphocyte recognition of human group 1 CD1 molecules: implications for innate and acquired immunity.
Authors: Authors: Sugita M, Brenner MB.
Semin Immunol
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T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity.
Authors: Authors: Bukowski JF, Roncarolo MG, Spits H, Krangel MS, Morita CT, Brenner MB, Band H.
Eur J Immunol
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Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.
Authors: Authors: Melián A, Watts GF, Shamshiev A, De Libero G, Clatworthy A, Vincent M, Brenner MB, Behar S, Niazi K, Modlin RL, Almo S, Ostrov D, Nathenson SG, Porcelli SA.
J Immunol
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