Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.

Authors: Authors: Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA.
Mol Cell 2001-12-01
View full abstract on Pubmed

Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

Authors: Authors: Sekiguchi JA, Whitlow S, Alt FW.
Mol Cell 2001-12-01
View full abstract on Pubmed

Influence of Mycobacterium bovis bacillus Calmette Guérin on in vitro induction of CD1 molecules in human adherent mononuclear cells.

Authors: Authors: Giuliani A, Prete SP, Graziani G, Aquino A, Balduzzi A, Sugita M, Brenner MB, Iona E, Fattorini L, Orefici G, Porcelli SA, Bonmassar E.
Infect Immun 2001-12-01
View full abstract on Pubmed

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.

Authors: Authors: Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW.
Nat Cell Biol 2001-10-01
View full abstract on Pubmed

TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.

Authors: Authors: Tsitsikov EN, Laouini D, Dunn IF, Sannikova TY, Davidson L, Alt FW, Geha RS.
Immunity 2001-10-01
View full abstract on Pubmed

DNA double strand break repair and chromosomal translocation: lessons from animal models.

Authors: Authors: Ferguson DO, Alt FW.
Oncogene 2001-09-10
View full abstract on Pubmed

CD1-specific T cells in microbial immunity.

Authors: Authors: Gumperz JE, Brenner MB.
Curr Opin Immunol 2001-08-01
View full abstract on Pubmed

Plasma cell differentiation requires the transcription factor XBP-1.

Authors: Authors: Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH.
Nature 2001-07-19
View full abstract on Pubmed

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.

Authors: Authors: Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW.
Proc Natl Acad Sci U S A 2001-03-13
View full abstract on Pubmed

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.

Authors: Authors: de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW.
Immunity 2001-01-01
View full abstract on Pubmed