Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice.
Authors: Authors: Gärtner F, Alt FW, Monroe RJ, Seidl KJ.
J Exp Med
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T lymphocyte recognition of human group 1 CD1 molecules: implications for innate and acquired immunity.
Authors: Authors: Sugita M, Brenner MB.
Semin Immunol
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T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity.
Authors: Authors: Bukowski JF, Roncarolo MG, Spits H, Krangel MS, Morita CT, Brenner MB, Band H.
Eur J Immunol
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Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.
Authors: Authors: Melián A, Watts GF, Shamshiev A, De Libero G, Clatworthy A, Vincent M, Brenner MB, Behar S, Niazi K, Modlin RL, Almo S, Ostrov D, Nathenson SG, Porcelli SA.
J Immunol
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CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection.
Authors: Authors: Moody DB, Guy MR, Grant E, Cheng TY, Brenner MB, Besra GS, Porcelli SA.
J Exp Med
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T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines.
Authors: Authors: Agace WW, Higgins JM, Sadasivan B, Brenner MB, Parker CM.
Curr Opin Cell Biol
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Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells.
Authors: Authors: Krawczyk C, Bachmaier K, Sasaki T, Jones RG, Snapper SB, Bouchard D, Kozieradzki I, Ohashi PS, Alt FW, Penninger JM.
Immunity
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RNA editing meets DNA shuffling.
Authors: Authors: Tian M, Alt FW.
Nature
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Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
Authors: Authors: O'Hagan RC, Ohh M, David G, de Alboran IM, Alt FW, Kaelin WG, DePinho RA.
Genes Dev
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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Authors: Authors: Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA.
Nat Genet
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