Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

RNA editing meets DNA shuffling.
Authors: Authors: Tian M, Alt FW.
Nature
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Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
Authors: Authors: O'Hagan RC, Ohh M, David G, de Alboran IM, Alt FW, Kaelin WG, DePinho RA.
Genes Dev
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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Authors: Authors: Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA.
Nat Genet
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Vav family proteins couple to diverse cell surface receptors.
Authors: Authors: Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W.
Mol Cell Biol
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The role of alpha and beta chains in ligand recognition by beta 7 integrins.
Authors: Authors: Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB.
J Biol Chem
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Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro.
Authors: Authors: Tian M, Alt FW.
J Biol Chem
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CD1c molecules broadly survey the endocytic system.
Authors: Authors: Sugita M, van Der Wel N, Rogers RA, Peters PJ, Brenner MB.
Proc Natl Acad Sci U S A
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Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments.
Authors: Authors: Sleckman BP, Bassing CH, Hughes MM, Okada A, D'Auteuil M, Wehrly TD, Woodman BB, Davidson L, Chen J, Alt FW.
Proc Natl Acad Sci U S A
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Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.
Authors: Authors: Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW.
Curr Biol
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The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.
Authors: Authors: Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW.
Proc Natl Acad Sci U S A
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