Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments.
Authors: Authors: Sleckman BP, Bassing CH, Hughes MM, Okada A, D'Auteuil M, Wehrly TD, Woodman BB, Davidson L, Chen J, Alt FW.
Proc Natl Acad Sci U S A
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Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.
Authors: Authors: Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW.
Curr Biol
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The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.
Authors: Authors: Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW.
Proc Natl Acad Sci U S A
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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
Authors: Authors: Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW.
Mol Cell
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Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene.
Authors: Authors: Sleckman BP, Khan WN, Xu W, Bassing CH, Malynn BA, Copeland NG, Bardon CG, Breit TM, Davidson L, Oltz EM, Jenkins NA, Berman JE, Alt FW.
Mol Cell Biol
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N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
Authors: Authors: Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW.
Genes Dev
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Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.
Authors: Authors: Bassing CH, Alt FW, Hughes MM, D'Auteuil M, Wehrly TD, Woodman BB, Gärtner F, White JM, Davidson L, Sleckman BP.
Nature
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Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin.
Authors: Authors: Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB.
J Exp Med
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Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions.
Authors: Authors: Sieling PA, Ochoa MT, Jullien D, Leslie DS, Sabet S, Rosat JP, Burdick AE, Rea TH, Brenner MB, Porcelli SA, Modlin RL.
J Immunol
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CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection.
Authors: Authors: Moody DB, Ulrichs T, Mühlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, Porcelli SA.
Nature
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