Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
Authors: Authors: Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW.
Genes Dev
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Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin.
Authors: Authors: Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB.
J Exp Med
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Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions.
Authors: Authors: Sieling PA, Ochoa MT, Jullien D, Leslie DS, Sabet S, Rosat JP, Burdick AE, Rea TH, Brenner MB, Porcelli SA, Modlin RL.
J Immunol
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CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection.
Authors: Authors: Moody DB, Ulrichs T, Mühlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, Porcelli SA.
Nature
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Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.
Authors: Authors: Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW.
Nature
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Pathways for lipid antigen presentation by CD1 molecules: nowhere for intracellular pathogens to hide.
Authors: Authors: Sugita M, Peters PJ, Brenner MB.
Traffic
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Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.
Authors: Authors: Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y.
Proc Natl Acad Sci U S A
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Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity.
Authors: Authors: Spada FM, Grant EP, Peters PJ, Sugita M, Melián A, Leslie DS, Lee HK, van Donselaar E, Hanson DA, Krensky AM, Majdic O, Porcelli SA, Morita CT, Brenner MB.
J Exp Med
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Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
Authors: Authors: Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW.
Proc Natl Acad Sci U S A
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Murine CD1d-restricted T cell recognition of cellular lipids.
Authors: Authors: Gumperz JE, Roy C, Makowska A, Lum D, Sugita M, Podrebarac T, Koezuka Y, Porcelli SA, Cardell S, Brenner MB, Behar SM.
Immunity
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