Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

IQGAP1 and calmodulin modulate E-cadherin function.

Authors: Authors: Li Z, Kim SH, Higgins JM, Brenner MB, Sacks DB.
J Biol Chem 1999-12-31
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Separate pathways for antigen presentation by CD1 molecules.

Authors: Authors: Sugita M, Grant EP, van Donselaar E, Hsu VW, Rogers RA, Peters PJ, Brenner MB.
Immunity 1999-12-01
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Conservation of a CD1 multigene family in the guinea pig.

Authors: Authors: Dascher CC, Hiromatsu K, Naylor JW, Brauer PP, Brown KA, Storey JR, Behar SM, Kawasaki ES, Porcelli SA, Brenner MB, LeClair KP.
J Immunol 1999-11-15
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RAG2 is regulated differentially in B and T cells by elements 5' of the promoter.

Authors: Authors: Monroe RJ, Chen F, Ferrini R, Davidson L, Alt FW.
Proc Natl Acad Sci U S A 1999-10-26
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Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.

Authors: Authors: Aifantis I, Pivniouk VI, Gärtner F, Feinberg J, Swat W, Alt FW, von Boehmer H, Geha RS.
J Exp Med 1999-10-18
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The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination.

Authors: Authors: Sakai E, Bottaro A, Alt FW.
Int Immunol 1999-10-01
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RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues.

Authors: Authors: Monroe RJ, Seidl KJ, Gaertner F, Han S, Chen F, Sekiguchi J, Wang J, Ferrini R, Davidson L, Kelsoe G, Alt FW.
Immunity 1999-08-01
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Lymphocyte adhesion to epithelia and endothelia mediated by the lymphocyte endothelial-epithelial cell adhesion molecule glycoprotein.

Authors: Authors: Shieh CC, Sadasivan BK, Russell GJ, Schön MP, Parker CM, Brenner MB.
J Immunol 1999-08-01
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Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation.

Authors: Authors: Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC.
Biochem Soc Trans 1999-08-01
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Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity.

Authors: Authors: Bukowski JF, Morita CT, Brenner MB.
Immunity 1999-07-01
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