Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis.

Authors: Authors: Behar SM, Dascher CC, Grusby MJ, Wang CR, Brenner MB.
J Exp Med 1999-06-21
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Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.

Authors: Authors: Schön MP, Arya A, Murphy EA, Adams CM, Strauch UG, Agace WW, Marsal J, Donohue JP, Her H, Beier DR, Olson S, Lefrancois L, Brenner MB, Grusby MJ, Parker CM.
J Immunol 1999-06-01
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Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients.

Authors: Authors: Wang Z, Yunis D, Irigoyen M, Kitchens B, Bottaro A, Alt FW, Alper CA.
Clin Immunol 1999-06-01
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Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.

Authors: Authors: Gärtner F, Alt FW, Monroe R, Chu M, Sleckman BP, Davidson L, Swat W.
Immunity 1999-05-01
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Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer.

Authors: Authors: Monroe RJ, Sleckman BP, Monroe BC, Khor B, Claypool S, Ferrini R, Davidson L, Alt FW.
Immunity 1999-05-01
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Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1-deficient mice.

Authors: Authors: Chen YH, Wang B, Chun T, Zhao L, Cardell S, Behar SM, Brenner MB, Wang CR.
J Immunol 1999-04-15
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Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

Authors: Authors: Seidl KJ, Manis JP, Bottaro A, Zhang J, Davidson L, Kisselgof A, Oettgen H, Alt FW.
Proc Natl Acad Sci U S A 1999-03-16
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Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.

Authors: Authors: Shaw AC, Swat W, Davidson L, Alt FW.
Proc Natl Acad Sci U S A 1999-03-02
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Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.

Authors: Authors: Sakai E, Bottaro A, Davidson L, Sleckman BP, Alt FW.
Proc Natl Acad Sci U S A 1999-02-16
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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

Authors: Authors: Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC.
Science 1999-01-15
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