Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Molecular recognition of lipid antigens by T cell receptors.
Authors: Authors: Grant EP, Degano M, Rosat JP, Stenger S, Modlin RL, Wilson IA, Porcelli SA, Brenner MB.
J Exp Med
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Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes.
Authors: Authors: Shaw AC, Swat W, Ferrini R, Davidson L, Alt FW.
J Exp Med
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CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool.
Authors: Authors: Rosat JP, Grant EP, Beckman EM, Dascher CC, Sieling PA, Frederique D, Modlin RL, Porcelli SA, Furlong ST, Brenner MB.
J Immunol
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Membrane anchoring of calnexin facilitates its interaction with its targets.
Authors: Authors: Ho SC, Rajagopalan S, Chaudhuri S, Shieh CC, Brenner MB, Pillai S.
Mol Immunol
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Diverse TCRs recognize murine CD1.
Authors: Authors: Behar SM, Podrebarac TA, Roy CJ, Wang CR, Brenner MB.
J Immunol
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Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis.
Authors: Authors: Sekiguchi JM, Gao Y, Gu Y, Frank K, Sun Y, Chaudhuri J, Zhu C, Cheng HL, Manis J, Ferguson D, Davidson L, Greenberg ME, Alt FW.
Cold Spring Harb Symp Quant Biol
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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.
Authors: Authors: Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW.
Cell
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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.
Authors: Authors: Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL, Davidson L, Kangaloo L, Alt FW.
Nature
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An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching.
Authors: Authors: Seidl KJ, Bottaro A, Vo A, Zhang J, Davidson L, Alt FW.
Int Immunol
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Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion.
Authors: Authors: Sleckman BP, Khor B, Monroe R, Alt FW.
J Exp Med
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