Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

Authors: Authors: Seidl KJ, Manis JP, Bottaro A, Zhang J, Davidson L, Kisselgof A, Oettgen H, Alt FW.
Proc Natl Acad Sci U S A 1999-03-16
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Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.

Authors: Authors: Shaw AC, Swat W, Davidson L, Alt FW.
Proc Natl Acad Sci U S A 1999-03-02
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Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.

Authors: Authors: Sakai E, Bottaro A, Davidson L, Sleckman BP, Alt FW.
Proc Natl Acad Sci U S A 1999-02-16
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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

Authors: Authors: Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC.
Science 1999-01-15
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Molecular recognition of lipid antigens by T cell receptors.

Authors: Authors: Grant EP, Degano M, Rosat JP, Stenger S, Modlin RL, Wilson IA, Porcelli SA, Brenner MB.
J Exp Med 1999-01-04
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Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes.

Authors: Authors: Shaw AC, Swat W, Ferrini R, Davidson L, Alt FW.
J Exp Med 1999-01-04
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CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool.

Authors: Authors: Rosat JP, Grant EP, Beckman EM, Dascher CC, Sieling PA, Frederique D, Modlin RL, Porcelli SA, Furlong ST, Brenner MB.
J Immunol 1999-01-01
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Membrane anchoring of calnexin facilitates its interaction with its targets.

Authors: Authors: Ho SC, Rajagopalan S, Chaudhuri S, Shieh CC, Brenner MB, Pillai S.
Mol Immunol 1999-01-01
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Diverse TCRs recognize murine CD1.

Authors: Authors: Behar SM, Podrebarac TA, Roy CJ, Wang CR, Brenner MB.
J Immunol 1999-01-01
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Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis.

Authors: Authors: Sekiguchi JM, Gao Y, Gu Y, Frank K, Sun Y, Chaudhuri J, Zhu C, Cheng HL, Manis J, Ferguson D, Davidson L, Greenberg ME, Alt FW.
Cold Spring Harb Symp Quant Biol 1999-01-01
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