Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Diverse TCRs recognize murine CD1.

Authors: Authors: Behar SM, Podrebarac TA, Roy CJ, Wang CR, Brenner MB.
J Immunol 1999-01-01
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Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis.

Authors: Authors: Sekiguchi JM, Gao Y, Gu Y, Frank K, Sun Y, Chaudhuri J, Zhu C, Cheng HL, Manis J, Ferguson D, Davidson L, Greenberg ME, Alt FW.
Cold Spring Harb Symp Quant Biol 1999-01-01
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CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool.

Authors: Authors: Rosat JP, Grant EP, Beckman EM, Dascher CC, Sieling PA, Frederique D, Modlin RL, Porcelli SA, Furlong ST, Brenner MB.
J Immunol 1999-01-01
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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.

Authors: Authors: Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW.
Cell 1998-12-23
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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.

Authors: Authors: Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL, Davidson L, Kangaloo L, Alt FW.
Nature 1998-11-12
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An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching.

Authors: Authors: Seidl KJ, Bottaro A, Vo A, Zhang J, Davidson L, Alt FW.
Int Immunol 1998-11-01
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Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion.

Authors: Authors: Sleckman BP, Khor B, Monroe R, Alt FW.
J Exp Med 1998-10-19
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Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

Authors: Authors: Manis JP, van der Stoep N, Tian M, Ferrini R, Davidson L, Bottaro A, Alt FW.
J Exp Med 1998-10-19
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Accessibility control of variable region gene assembly during T-cell development.

Authors: Authors: Sleckman BP, Bassing CH, Bardon CG, Okada A, Khor B, Bories JC, Monroe R, Alt FW.
Immunol Rev 1998-10-01
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Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.

Authors: Authors: Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON.
J Exp Med 1998-09-07
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