Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.
Authors: Authors: Manis JP, van der Stoep N, Tian M, Ferrini R, Davidson L, Bottaro A, Alt FW.
J Exp Med
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Accessibility control of variable region gene assembly during T-cell development.
Authors: Authors: Sleckman BP, Bassing CH, Bardon CG, Okada A, Khor B, Bories JC, Monroe R, Alt FW.
Immunol Rev
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Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
Authors: Authors: Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON.
J Exp Med
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A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination.
Authors: Authors: Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, Alt FW.
Immunity
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Migration of intestinal intraepithelial lymphocytes into a polarized epithelial monolayer.
Authors: Authors: Shaw SK, Hermanowski-Vosatka A, Shibahara T, McCormick BA, Parkos CA, Carlson SL, Ebert EC, Brenner MB, Madara JL.
Am J Physiol
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Germline transcription and recombination of a murine VDJmudeltagamma1 transgene.
Authors: Authors: Cunningham K, Ackerly H, Claflin L, Collins J, Wu P, Ford C, Lansford R, Alt F, Dunnick WA.
Int Immunol
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The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.
Authors: Authors: Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, Alt FW, Gilliland DG, Golub TR, Orkin SH.
Genes Dev
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The CD1 family of lipid antigen-presenting molecules.
Authors: Authors: Porcelli SA, Segelke BW, Sugita M, Wilson IA, Brenner MB.
Immunol Today
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Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.
Authors: Authors: Pivniouk V, Tsitsikov E, Swinton P, Rathbun G, Alt FW, Geha RS.
Cell
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Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.
Authors: Authors: Snapper SB, Rosen FS, Mizoguchi E, Cohen P, Khan W, Liu CH, Hagemann TL, Kwan SP, Ferrini R, Davidson L, Bhan AK, Alt FW.
Immunity
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