Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Crucial role of TCR gamma chain junctional region in prenyl pyrophosphate antigen recognition by gamma delta T cells.
Authors: Authors: Bukowski JF, Morita CT, Band H, Brenner MB.
J Immunol
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Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.
Authors: Authors: Manis JP, Gu Y, Lansford R, Sonoda E, Ferrini R, Davidson L, Rajewsky K, Alt FW.
J Exp Med
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Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus.
Authors: Authors: Bottaro A, Young F, Chen J, Serwe M, Sablitzky F, Alt FW.
Int Immunol
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Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation.
Authors: Authors: van der Stoep N, Gorman JR, Alt FW.
Immunity
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Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains.
Authors: Authors: Irving BA, Alt FW, Killeen N.
Science
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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction.
Authors: Authors: Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS, Alt FW, Crabtree GR.
Curr Biol
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SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.
Authors: Authors: Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW.
Immunity
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Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production.
Authors: Authors: Hata D, Kawakami Y, Inagaki N, Lantz CS, Kitamura T, Khan WN, Maeda-Yamamoto M, Miura T, Han W, Hartman SE, Yao L, Nagai H, Goldfeld AE, Alt FW, Galli SJ, Witte ON, Kawakami T.
J Exp Med
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Potential regulatory elements for germline transcription in or near murine Sgamma1.
Authors: Authors: Cunningham K, Ackerly H, Alt F, Dunnick W.
Int Immunol
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CD1--a new paradigm for antigen presentation and T cell activation.
Authors: Authors: Sugita M, Moody DB, Jackman RM, Grant EP, Rosat JP, Behar SM, Peters PJ, Porcelli SA, Brenner MB.
Clin Immunol Immunopathol
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