Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.

Authors: Authors: Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, Alt FW, Gilliland DG, Golub TR, Orkin SH.
Genes Dev 1998-08-01
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The CD1 family of lipid antigen-presenting molecules.

Authors: Authors: Porcelli SA, Segelke BW, Sugita M, Wilson IA, Brenner MB.
Immunol Today 1998-08-01
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Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

Authors: Authors: Pivniouk V, Tsitsikov E, Swinton P, Rathbun G, Alt FW, Geha RS.
Cell 1998-07-24
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Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.

Authors: Authors: Snapper SB, Rosen FS, Mizoguchi E, Cohen P, Khan W, Liu CH, Hagemann TL, Kwan SP, Ferrini R, Davidson L, Bhan AK, Alt FW.
Immunity 1998-07-01
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Crucial role of TCR gamma chain junctional region in prenyl pyrophosphate antigen recognition by gamma delta T cells.

Authors: Authors: Bukowski JF, Morita CT, Band H, Brenner MB.
J Immunol 1998-07-01
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Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.

Authors: Authors: Manis JP, Gu Y, Lansford R, Sonoda E, Ferrini R, Davidson L, Rajewsky K, Alt FW.
J Exp Med 1998-06-15
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Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation.

Authors: Authors: van der Stoep N, Gorman JR, Alt FW.
Immunity 1998-06-01
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Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus.

Authors: Authors: Bottaro A, Young F, Chen J, Serwe M, Sablitzky F, Alt FW.
Int Immunol 1998-06-01
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Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains.

Authors: Authors: Irving BA, Alt FW, Killeen N.
Science 1998-05-08
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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction.

Authors: Authors: Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS, Alt FW, Crabtree GR.
Curr Biol 1998-05-07
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