Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.

Authors: Authors: Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW.
Immunity 1998-05-01
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Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production.

Authors: Authors: Hata D, Kawakami Y, Inagaki N, Lantz CS, Kitamura T, Khan WN, Maeda-Yamamoto M, Miura T, Han W, Hartman SE, Yao L, Nagai H, Goldfeld AE, Alt FW, Galli SJ, Witte ON, Kawakami T.
J Exp Med 1998-04-20
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Potential regulatory elements for germline transcription in or near murine Sgamma1.

Authors: Authors: Cunningham K, Ackerly H, Alt F, Dunnick W.
Int Immunol 1998-04-01
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CD1--a new paradigm for antigen presentation and T cell activation.

Authors: Authors: Sugita M, Moody DB, Jackman RM, Grant EP, Rosat JP, Behar SM, Peters PJ, Porcelli SA, Brenner MB.
Clin Immunol Immunopathol 1998-04-01
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Ig heavy chain class switching in Rag-deficient mice.

Authors: Authors: Lansford R, Manis JP, Sonoda E, Rajewsky K, Alt FW.
Int Immunol 1998-03-01
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Clonally expanded Valpha12+ (AV12S1),CD8+ T cells from a patient with rheumatoid arthritis are autoreactive.

Authors: Authors: Behar SM, Roy C, Lederer J, Fraser P, Brenner MB.
Arthritis Rheum 1998-03-01
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Rifampin increases cytokine-induced expression of the CD1b molecule in human peripheral blood monocytes.

Authors: Authors: Tentori L, Graziani G, Porcelli SA, Sugita M, Brenner MB, Madaio R, Bonmassar E, Giuliani A, Aquino A.
Antimicrob Agents Chemother 1998-03-01
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Structure of the Vdelta domain of a human gammadelta T-cell antigen receptor.

Authors: Authors: Li H, Lebedeva MI, Llera AS, Fields BA, Brenner MB, Mariuzza RA.
Nature 1998-01-29
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Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin.

Authors: Authors: Higgins JM, Mandlebrot DA, Shaw SK, Russell GJ, Murphy EA, Chen YT, Nelson WJ, Parker CM, Brenner MB.
J Cell Biol 1998-01-12
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Effect of rifampin on CD1b expression and double-negative T cell responses against mycobacteria-derived glycolipid antigen.

Authors: Authors: Giuliani A, Porcelli SA, Tentori L, Graziani G, Testorelli C, Prete SP, Bussini S, Cappelletti D, Brenner MB, Bonmassar E, Aquino A.
Life Sci 1998-01-01
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