Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors.

Authors: Authors: Fraefel C, Jacoby DR, Lage C, Hilderbrand H, Chou JY, Alt FW, Breakefield XO, Majzoub JA.
Mol Med 1997-12-01
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Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

Authors: Authors: Gu Y, Seidl KJ, Rathbun GA, Zhu C, Manis JP, van der Stoep N, Davidson L, Cheng HL, Sekiguchi JM, Frank K, Stanhope-Baker P, Schlissel MS, Roth DB, Alt FW.
Immunity 1997-11-01
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Molecular genetic characterization of XRCC4 function.

Authors: Authors: Mizuta R, Cheng HL, Gao Y, Alt FW.
Int Immunol 1997-10-01
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Function of the TCR alpha enhancer in alphabeta and gammadelta T cells.

Authors: Authors: Sleckman BP, Bardon CG, Ferrini R, Davidson L, Alt FW.
Immunity 1997-10-01
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Assembly and retention of CD1b heavy chains in the endoplasmic reticulum.

Authors: Authors: Sugita M, Porcelli SA, Brenner MB.
J Immunol 1997-09-01
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Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development.

Authors: Authors: Porter FD, Drago J, Xu Y, Cheema SS, Wassif C, Huang SP, Lee E, Grinberg A, Massalas JS, Bodine D, Alt F, Westphal H.
Development 1997-08-01
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Antigen presentation: mixing oil and water.

Authors: Authors: Porcelli SA, Brenner MB.
Curr Biol 1997-08-01
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V(D)J recombination. From RAGs to stitches.

Authors: Authors: Weaver DT, Alt FW.
Nature 1997-07-31
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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

Authors: Authors: Gu Y, Jin S, Gao Y, Weaver DT, Alt FW.
Proc Natl Acad Sci U S A 1997-07-22
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Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains.

Authors: Authors: Suzuki H, Shinkai Y, Granger LG, Alt FW, Love PE, Singer A.
J Exp Med 1997-07-07
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