Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.

Authors: Authors: Mizuta R, LaSalle JM, Cheng HL, Shinohara A, Ogawa H, Copeland N, Jenkins NA, Lalande M, Alt FW.
Proc Natl Acad Sci U S A 1997-06-24
View full abstract on Pubmed

Differential effects of cytolytic T cell subsets on intracellular infection.

Authors: Authors: Stenger S, Mazzaccaro RJ, Uyemura K, Cho S, Barnes PF, Rosat JP, Sette A, Brenner MB, Porcelli SA, Bloom BR, Modlin RL.
Science 1997-06-13
View full abstract on Pubmed

The absence of the transcription activator TFE3 impairs activation of B cells in vivo.

Authors: Authors: Merrell K, Wells S, Henderson A, Gorman J, Alt F, Stall A, Calame K.
Mol Cell Biol 1997-06-01
View full abstract on Pubmed

Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.

Authors: Authors: Kawakami Y, Miura T, Bissonnette R, Hata D, Khan WN, Kitamura T, Maeda-Yamamoto M, Hartman SE, Yao L, Alt FW, Kawakami T.
Proc Natl Acad Sci U S A 1997-04-15
View full abstract on Pubmed

Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor.

Authors: Authors: Van Parijs L, Biuckians A, Ibragimov A, Alt FW, Willerford DM, Abbas AK.
J Immunol 1997-04-15
View full abstract on Pubmed

Cytokine-induced expression of CD1b molecules by peripheral blood monocytes: influence of 3'-azido-3'-deoxythymidine.

Authors: Authors: Giuliani A, Tentori L, Pepponi R, Porcelli SA, Aquino A, Orlando L, Sugita M, Brenner MB, Bonmassar E, Graziani G.
Pharmacol Res 1997-03-01
View full abstract on Pubmed

The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules.

Authors: Authors: Prigozy TI, Sieling PA, Clemens D, Stewart PL, Behar SM, Porcelli SA, Brenner MB, Modlin RL, Kronenberg M.
Immunity 1997-03-01
View full abstract on Pubmed

Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40.

Authors: Authors: Khan WN, Nilsson A, Mizoguchi E, Castigli E, Forsell J, Bhan AK, Geha R, Sideras P, Alt FW.
Int Immunol 1997-03-01
View full abstract on Pubmed

Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells.

Authors: Authors: Young F, Mizoguchi E, Bhan AK, Alt FW.
Immunity 1997-01-01
View full abstract on Pubmed

Cloning, expression, and crystallization of the V delta domain of a human gamma delta T-cell receptor.

Authors: Authors: Lebedeva MI, Fields BA, Spits H, Panchamoorthy G, Brenner MB, Mariuzza RA.
Protein Sci 1996-12-01
View full abstract on Pubmed