Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Function of the TCR alpha enhancer in alphabeta and gammadelta T cells.

Authors: Authors: Sleckman BP, Bardon CG, Ferrini R, Davidson L, Alt FW.
Immunity 1997-10-01
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Assembly and retention of CD1b heavy chains in the endoplasmic reticulum.

Authors: Authors: Sugita M, Porcelli SA, Brenner MB.
J Immunol 1997-09-01
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Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development.

Authors: Authors: Porter FD, Drago J, Xu Y, Cheema SS, Wassif C, Huang SP, Lee E, Grinberg A, Massalas JS, Bodine D, Alt F, Westphal H.
Development 1997-08-01
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Antigen presentation: mixing oil and water.

Authors: Authors: Porcelli SA, Brenner MB.
Curr Biol 1997-08-01
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V(D)J recombination. From RAGs to stitches.

Authors: Authors: Weaver DT, Alt FW.
Nature 1997-07-31
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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

Authors: Authors: Gu Y, Jin S, Gao Y, Weaver DT, Alt FW.
Proc Natl Acad Sci U S A 1997-07-22
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Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains.

Authors: Authors: Suzuki H, Shinkai Y, Granger LG, Alt FW, Love PE, Singer A.
J Exp Med 1997-07-07
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RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.

Authors: Authors: Mizuta R, LaSalle JM, Cheng HL, Shinohara A, Ogawa H, Copeland N, Jenkins NA, Lalande M, Alt FW.
Proc Natl Acad Sci U S A 1997-06-24
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Differential effects of cytolytic T cell subsets on intracellular infection.

Authors: Authors: Stenger S, Mazzaccaro RJ, Uyemura K, Cho S, Barnes PF, Rosat JP, Sette A, Brenner MB, Porcelli SA, Bloom BR, Modlin RL.
Science 1997-06-13
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The absence of the transcription activator TFE3 impairs activation of B cells in vivo.

Authors: Authors: Merrell K, Wells S, Henderson A, Gorman J, Alt F, Stall A, Calame K.
Mol Cell Biol 1997-06-01
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