Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.

Authors: Authors: Wang Q, Stacy T, Miller JD, Lewis AF, Gu TL, Huang X, Bushweller JH, Bories JC, Alt FW, Ryan G, Liu PP, Wynshaw-Boris A, Binder M, Marín-Padilla M, Sharpe AH, Speck NA.
Cell 1996-11-15
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p126 (CDw101), a costimulatory molecule preferentially expressed on mucosal T lymphocytes.

Authors: Authors: Russell GJ, Parker CM, Sood A, Mizoguchi E, Ebert EC, Bhan AK, Brenner MB.
J Immunol 1996-10-15
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Developmental regulation of V(D)J recombination and lymphocyte differentiation.

Authors: Authors: Willerford DM, Swat W, Alt FW.
Curr Opin Genet Dev 1996-10-01
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The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes.

Authors: Authors: Gorman JR, van der Stoep N, Monroe R, Cogne M, Davidson L, Alt FW.
Immunity 1996-09-01
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The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene.

Authors: Authors: Mizuta R, Taccioli GE, Alt FW.
Int Immunol 1996-09-01
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Abnormal peripheral lymphocyte function in c-abl mutant mice.

Authors: Authors: Hardin JD, Boast S, Schwartzberg PL, Lee G, Alt FW, Stall AM, Goff SP.
Cell Immunol 1996-08-25
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Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

Authors: Authors: Bories JC, Demengeot J, Davidson L, Alt FW.
Proc Natl Acad Sci U S A 1996-07-23
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Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs.

Authors: Authors: Sugita M, Jackman RM, van Donselaar E, Behar SM, Rogers RA, Peters PJ, Brenner MB, Porcelli SA.
Science 1996-07-19
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The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.

Authors: Authors: Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH.
Cell 1996-07-12
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Expression of a candidate cadherin in T lymphocytes.

Authors: Authors: Cepek KL, Rimm DL, Brenner MB.
Proc Natl Acad Sci U S A 1996-06-25
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