Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

Authors: Authors: Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E, Alt FW, Westphal H.
Proc Natl Acad Sci U S A 1996-06-11
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Direct presentation of non-peptide prenyl pyrophosphate antigens to human gamma delta T cells.

Authors: Authors: Morita CT, Tanaka Y, Bloom BR, Brenner MB.
Res Immunol 1996-06-01
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Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.

Authors: Authors: Swat W, Shinkai Y, Cheng HL, Davidson L, Alt FW.
Proc Natl Acad Sci U S A 1996-05-14
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Recognition of nonpeptide antigens by T cells.

Authors: Authors: Tanaka Y, Brenner MB, Bloom BR, Morita CT.
J Mol Med (Berl) 1996-05-01
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Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement.

Authors: Authors: Xu Y, Davidson L, Alt FW, Baltimore D.
Immunity 1996-04-01
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Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.

Authors: Authors: Xu Y, Davidson L, Alt FW, Baltimore D.
Proc Natl Acad Sci U S A 1996-03-05
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CD40 expression and function in murine B cell ontogeny.

Authors: Authors: Castigli E, Young F, Carossino AM, Alt FW, Geha RS.
Int Immunol 1996-03-01
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Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin.

Authors: Authors: Diacovo TG, Roth SJ, Morita CT, Rosat JP, Brenner MB, Springer TA.
J Exp Med 1996-03-01
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Antigen presentation by CD1 and MHC-encoded class I-like molecules.

Authors: Authors: Melián A, Beckman EM, Porcelli SA, Brenner MB.
Curr Opin Immunol 1996-03-01
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T cell responses in calcineurin A alpha-deficient mice.

Authors: Authors: Zhang BW, Zimmer G, Chen J, Ladd D, Li E, Alt FW, Wiederrecht G, Cryan J, O'Neill EA, Seidman CE, Abbas AK, Seidman JG.
J Exp Med 1996-02-01
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