Frederick Alt, Ph.D.
Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.
Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.
Authors: Authors: Bories JC, Demengeot J, Davidson L, Alt FW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs.
Authors: Authors: Sugita M, Jackman RM, van Donselaar E, Behar SM, Rogers RA, Peters PJ, Brenner MB, Porcelli SA.
Science
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Science
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The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.
Authors: Authors: Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH.
Cell
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Cell
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Expression of a candidate cadherin in T lymphocytes.
Authors: Authors: Cepek KL, Rimm DL, Brenner MB.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
Authors: Authors: Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E, Alt FW, Westphal H.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Direct presentation of non-peptide prenyl pyrophosphate antigens to human gamma delta T cells.
Authors: Authors: Morita CT, Tanaka Y, Bloom BR, Brenner MB.
Res Immunol
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Res Immunol
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Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.
Authors: Authors: Swat W, Shinkai Y, Cheng HL, Davidson L, Alt FW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Recognition of nonpeptide antigens by T cells.
Authors: Authors: Tanaka Y, Brenner MB, Bloom BR, Morita CT.
J Mol Med (Berl)
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J Mol Med (Berl)
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Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement.
Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.
Authors: Authors: Xu Y, Davidson L, Alt FW, Baltimore D.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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