Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin.

Authors: Authors: Diacovo TG, Roth SJ, Morita CT, Rosat JP, Brenner MB, Springer TA.
J Exp Med 1996-03-01
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Antigen presentation by CD1 and MHC-encoded class I-like molecules.

Authors: Authors: Melián A, Beckman EM, Porcelli SA, Brenner MB.
Curr Opin Immunol 1996-03-01
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CD40 expression and function in murine B cell ontogeny.

Authors: Authors: Castigli E, Young F, Carossino AM, Alt FW, Geha RS.
Int Immunol 1996-03-01
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T cell responses in calcineurin A alpha-deficient mice.

Authors: Authors: Zhang BW, Zimmer G, Chen J, Ladd D, Li E, Alt FW, Wiederrecht G, Cryan J, O'Neill EA, Seidman CE, Abbas AK, Seidman JG.
J Exp Med 1996-02-01
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Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements.

Authors: Authors: Sleckman BP, Gorman JR, Alt FW.
Annu Rev Immunol 1996-01-01
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Identification of the XRCC4 gene: complementation of the DSBR and V(D)J recombination defects of XR-1 cells.

Authors: Authors: Li Z, Alt FW.
Curr Top Microbiol Immunol 1996-01-01
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Repertoires of antigen receptors in Tdt congenitally deficient mice.

Authors: Authors: Komori T, Pricop L, Hatakeyama A, Bona CA, Alt FW.
Int Rev Immunol 1996-01-01
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Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase family.

Authors: Authors: Dong C, Willerford D, Alt FW, Cooper MD.
Immunogenetics 1996-01-01
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The CD1-restricted T-cell response to mycobacteria.

Authors: Authors: Moody DB, Sugita M, Peters PJ, Brenner MB, Porcelli SA.
Res Immunol 1996-01-01
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The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.

Authors: Authors: Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD, Taccioli GE, Alt FW.
Cell 1995-12-29
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