Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Identification of the XRCC4 gene: complementation of the DSBR and V(D)J recombination defects of XR-1 cells.

Authors: Authors: Li Z, Alt FW.
Curr Top Microbiol Immunol 1996-01-01
View full abstract on Pubmed

Repertoires of antigen receptors in Tdt congenitally deficient mice.

Authors: Authors: Komori T, Pricop L, Hatakeyama A, Bona CA, Alt FW.
Int Rev Immunol 1996-01-01
View full abstract on Pubmed

Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase family.

Authors: Authors: Dong C, Willerford D, Alt FW, Cooper MD.
Immunogenetics 1996-01-01
View full abstract on Pubmed

The CD1-restricted T-cell response to mycobacteria.

Authors: Authors: Moody DB, Sugita M, Peters PJ, Brenner MB, Porcelli SA.
Res Immunol 1996-01-01
View full abstract on Pubmed

Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements.

Authors: Authors: Sleckman BP, Gorman JR, Alt FW.
Annu Rev Immunol 1996-01-01
View full abstract on Pubmed

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.

Authors: Authors: Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD, Taccioli GE, Alt FW.
Cell 1995-12-29
View full abstract on Pubmed

A pathway of costimulation that prevents anergy in CD28- T cells: B7-independent costimulation of CD1-restricted T cells.

Authors: Authors: Behar SM, Porcelli SA, Beckman EM, Brenner MB.
J Exp Med 1995-12-01
View full abstract on Pubmed

Promotion of V(D)J recombinational accessibility by the intronic E kappa element: role of the kappa B motif.

Authors: Authors: Demengeot J, Oltz EM, Alt FW.
Int Immunol 1995-12-01
View full abstract on Pubmed

A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion.

Authors: Authors: Blunt T, Taccioli GE, Priestley A, Hafezparast M, McMillan T, Liu J, Cole CC, White J, Alt FW, Jackson SP, et al.
Genomics 1995-11-20
View full abstract on Pubmed

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene.

Authors: Authors: Bories JC, Willerford DM, Grévin D, Davidson L, Camus A, Martin P, Stéhelin D, Alt FW.
Nature 1995-10-19
View full abstract on Pubmed